22312-61-4

Basic information

• Product Name: 2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE
• Synonyms: Benzanilide,2-amino-3'-chloro- (7CI,8CI)
• CAS NO: 22312-61-4
• Molecular Formula: C₁₃H₁₁ClN₂O
• Molecular Weight: 246.69
• Mol File: 22312-61-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 137-138 °C
• Boiling Point: 335.7°Cat760mmHg
• Flash Point: 156.8°C
• Appearance: /
• Density: 1.351
• Vapor Pressure: 0.000118mmHg at 25°C
• Refractive Index: 1.692
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 12.57±0.70(Predicted)
• CAS DataBase Reference: 2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE(22312-61-4)
• EPA Substance Registry System: 2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE(22312-61-4)

Safety Data

• Hazardous Substances Data: 22312-61-4(Hazardous Substances Data)

Usage

General Description

2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE is a chemical compound that belongs to the benzamide class and consists of an amine group and a benzene ring with a chlorine-substituted phenyl group. It is an important building block in organic synthesis and pharmaceutical research. 2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE has potential applications in the development of new drugs and pharmacological tools due to its ability to interact with various molecular targets in the body. Additionally, it has been studied for its potential antimicrobial and anticancer properties. The precise mechanisms of action and specific biological activities of 2-AMINO-N-(3-CHLOROPHENYL)BENZAMIDE are still being investigated, making it an important focus of ongoing research in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C13H11ClN2O/c14-9-4-3-5-10(8-9)16-13(17)11-6-1-2-7-12(11)15/h1-8H,15H2,(H,16,17)

Upstream product

• 108-42-9 3-chloro-aniline 
• 21563-73-5 2-aminobenzoyl chloride 
• 73544-84-0 2-nitro-N-(3-chlorophenyl)benzamide 
• 610-14-0 2-nitrobenzyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 
• 118-92-3 anthranilic acid 
• 118-48-9 isatoic anhydride 

Downstream Products

• 133040-63-8 3-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-ethyl]-3H-quinazolin-4-one 
• 39122-37-7 N-(3-chloro-phenyl)-2-nicotinoylamino-benzamide 
• 24122-26-7 3-(3-chlorophenyl)quinazolin-4(3H)-one 
• 99768-33-9 3-(3-chlorophenyl)benzo[d][1,2,3]triazin-4(3H)-one 
• 491-36-1 4-Hydroxyquinazoline 
• 340-94-3 2-methyl-3-(m-chlorophenyl)-4(3H)-quinazolinone 
• 1429192-29-9 3-(3-chlorophenyl)-2-(5-methylthiophen-2-yl)-2,3-dihydroquinazolin-4(1H)-one 

Relevant articles and documents

Method for reducing aromatic nitro into arylamine

The invention relates to a method for reducing aromatic nitro to arylamine. The method comprises the following steps: (1) taking an aromatic nitro compound as a raw material, water as a hydrogen source, a palladium compound, cheap and easy to obtain, as a catalyst and tetrahydroxydiboron as an additive to reduce nitro to obtain a product; (2) taking the aromatic nitro compound as the raw material, a copper salt, cheap and easy to obtain, as the catalyst, the tetrahydroxydiboron as the additive to reduce the nitro to obtain a product; and (3) taking the aromatic nitro compound as the raw material, water as the hydrogen source, and the tetrahydroxydiboron as the additive, without needing a metal catalyst, to reduce the nitro to obtain a product. A preparation method for the arylamine, which is provided by the invention, is mild in reaction condition, low in costs, environment-friendly, high in yield, and suitable for industrial production.

2 - (2 - Chlorophenyl) quinazoline -4 (3H) - ketone derivative as well as preparation method and application thereof (by machine translation)

The invention discloses 2 - (2 - chlorophenyl) quinazoline -4 (3H) - a ketone derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof. Compared, the traditional Chinese medicinal diazepam, midazolam, and midazolam

Sulfur-Promoted Synthesis of 2-Aroylquinazolin-4(3H)-ones by Oxidative Condensation of Anthranilamide and Acetophenones

A sulfur-promoted three-component reaction of isatoic anhydride, primary aliphatic or aromatic amines, and acetophenones leading to densely substituted 3-substituted 2-aroylquinazolin-4(3H)-ones is reported. The key step involves a cascade reaction of selective oxidation of the methyl group of the acetophenones, followed by a condensation with anthranilamides. The scope of the reaction is applicable to the synthesis of tryptanthrin and various 3-unsubstituted 2-aroylquinazolin-4(3H)-ones. (Figure presented.).