2233-84-3

Upstream product

• 6343-78-8 N-(o-hydroxybenzylidene)glycine 
• 90-02-8 salicylaldehyde 
• 56-40-6 glycine 
• 6343-78-8 N-salicylideneglycine 
• 98-67-9 p-hydoroxybenzenesulfonic acid 

Downstream Products

• 1000410-98-9 N-(2-hydroxybenzyl)-N-(2-picolyl)glycine 
• 35369-54-1 N,N-bis(2-hydroxylbenzyl)aminoacetic acid 
• 579-75-9 2-Methoxybenzoic acid 
• 55739-41-8 N-methyl-N-(2-methoxy)benzylglycine 

Relevant academic research and scientific papers

Reactions of boroxazolidones with aromatic aldehydes. An easy route to derivatives of isoquinoline and iso-indolinone

Boroxazolidones 1 derived from glycine and phenylalanine react with aromatic aldehydes to form the corresponding imines. The product 3 from 1a with o-carboxybenzaldehyde is converted into 4-hydroxyisoquinoline-3-carboxylic acid 6 by dimethyl sulfate, foll

The autoxidation activity of new mixed-ligand manganese and iron complexes with tripodal ligands

The activity of new manganese and iron complexes of dianionic tripodal ligands in the autoxidation of ethyl linoleate (EL) is reported. EL consumption rates were monitored using time-resolved FTIR and the degree of oligomerisation was determined by SEC. Almost all complexes showed the same trend in the autoxidation of EL. After a short induction time, the reaction started at a relatively high constant rate; later, this rate changes to a lower rate, which was again constant and on average was the same for all complexes studied. The observation that the autoxidation rate eventually became the same for all complexes can be explained with the assumption that a catalytic species was formed that was structurally similar for each complex. The crystal structure of a representative new complex, [Mn(papy)(acac)] (H2papy=N-(2-hydroxybenzyl)-N-(2-picolyl)-glycine; Hacac = acetylacetone), was elucidated, demonstrating a Jahn-Teller distorted octahedral geometry of the Mn(III) ion. To gain insight into the reaction mechanisms by which these manganese complexes react with peroxides, the reaction of [Mn(pppy)(dpm)] with alkyl hydroperoxides was studied using UV-vis and EPR spectroscopy (H2pppy = 2-[bis(2-hydroxybenzyl)aminomethyl]-pyridine; Hdpm = dipivaloylmethane). It is proposed that in a reaction of [Mn(pppy)(dpm)] with t-butyl hydroperoxide (tBuOOH), the species [Mn(III)(pppy)(OH)(tBuOOs)] is formed. In analogy with the formation of that species, which is postulated to occur through a reduction to Mn(II), it is proposed that in the direct initiation reaction of EL with a manganese(III) complex, a 1 electron-1 proton transfer reaction leads to the formation of Mn(II) and an EL radical. Considering parameters such as autoxidation activity, complex solubility and ease of complex preparation, the compound [Mn(III)(tbpppy)(dpm)] (H2tbpppy = 2-[bis(2-hydroxy-3,5-di-tert-butylbenzyl) aminomethyl]pyridine) is expected to be the best potential alkyd paint drier.

Amino acid derivatives and anti-inflammatory agents

Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally substituted 2-hydroxyaryl group, n is 0 or 1, R2repres

Magneto-structural correlation for binuclear octahedral vanadium(iv)-oxo complexes. Synthesis, structure and magnetic properties of a VIVO2+ complex with a new ligand derived from glycine

The synthesis of a new ligand, H3BBAC (N,N-bis(2-hydroxybenzyl)aminoacetic acid) and its first VIVO2+ complex, [Et3NH]2[O=V(BBAC)]2 (1), are presented in order to model the active site of vanadium tra

New Biologically Active Aromatic Derivatives of Fatty Acids

A convenient method for synthesizing the homologous series of new aromatic derivatives of fatty acids is described.The synthetic approach includes the reductive alkylation of ω- and α-amino acids with hydroxybenzaldehydes.The physicochemical properties of

ASSESSING THE EFFECT OF LIGAND PROXIMITY ON CHIROPTICAL AND OTHER PROPERTIES IN COBALT(III) MODEL, TYROSINE-LIKE COMPLEXES

A series of new cobalt(III) octahedral complexis of the general formula Na (ohb-aa=N-(o-hydroxybenzyl)amino acid anion; amino acid= glycine, (S)-α-alanine, α-aminoisobutyric acid, (S)-valine, (S)-norvaline and (S)-leucine) were prepared by th

Stereochemical factors affecting intramolecular interligand interaction in mixed ligand complexes

The binary and ternary complexes of the types , and have been studied, where M=Cu(II), Ni(II) and A = mannich bases synthesized by the condensation of different amino acids with salicylaldehyde, followed by reduction, such as, 2-(o-hydroxy

Phenolic Analogues of Amino Carboxylic Acid Ligands for 99mTc. IV N-(2-Hydroxybenzyl)glycines (hbg)

Ten tridentate ligands, N-(2-hydroxybenzyl)glycines (hbg) (5), were prepared by the Mannich reaction of a phenol with formaldehyde and glycine and/or by the reduction of the Schiff base of a substituted salicylaldehyde and glycine.In three instances the bis compounds (6b,c,i) were also formed by the first method.

SOLUTION STUDIES OF METAL(II) COMPLEXES OF THE MONOSODIUM SALT OF N-(2-HYDROXY-5-SULFO)BENZYLGLYCINE

pH-Metric investigations on the reaction of Cu2+, Ni2+ and Co2+ with the monosodium salt of N-(2-hydroxy-5-sulfo)benzylglycine in 1:1 and 1:2 metal:ligand mixtures in aqueous solution at 25 deg C and at an ionic strength of 0.1 M (NaClO4) showed the existence of MHL, ML- and ML(OH)2-, and MHL, MH2L22-, MHL23- and ML24- metal complex species.The stoichiometric equilibrium constants have been evaulated directly from the titration curves, both while ignoring and considering, the effect of metal ion hydrolysis and the proportion of the metal ion distributed among the various species over the experimental pH range has also been determined in each case by a modified algebraic approach.