223429-17-2

Upstream product

• 5664-21-1 cyclohexylacetaldehyde 
• 94-36-0 dibenzoyl peroxide 
• 223429-01-4 (1S,2R,4S,6S,7R)-4-((S)-Cyclohexyl-hydroxy-methyl)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]decane-5-carboxylic acid tert-butyl ester 
• 42134-55-4 (E)-3-cyclohexyl-2-propen-1-ol 
• 223429-11-6 (1S,2R,4S,6S,7R)-4-((S)-Benzoyloxy-cyclohexyl-methyl)-7,10,10-trimethyl-3-oxa-5-aza-tricyclo[5.2.1.0^2,6]decane-5-carboxylic acid tert-butyl ester 
• 111902-61-5 (2R,3R)-3-cyclohexyl-2,3-epoxypropan-1-ol 
• 887605-51-8 (1S,2R)-1-cyclohexyl-2,3-dihydroxypropyl benzoate 

Downstream Products

• 357952-91-1 (S)-(+)-1-Cyclohexyl-2-(p-tolylsulfonyloxy)ethanol 
• 3483-39-4 (S)-2-cyclohexyloxirane 
• 887605-52-9 (R)-1-cyclohexyl-4-(trimethylsilyl)but-3-yn-1-ol 
• 61414-09-3 (S)-1-cyclohexyl-1,2-ethanediol 

Relevant academic research and scientific papers

The silylalkyne-prins cyclization: Stereoselective synthesis of tetra- and pentasubstituted halodihydropyrans

A new type of Prins cyclization using silylated secondary homopropargylic alcohols and aldehydes yielding tetra- and pentasubstituted dihydropyrans is described. The presence of the trimethylsilyl group in the triple bond favors the Prins cyclization and

A novel chiral synthetic equivalent of glyoxal and its application to the asymmetric synthesis of O-protected α-hydroxy aldehydes

Diastereomerically pure 2-formyl-N-Boc-1,3-oxazolidine 7 was prepared in 83% yield from stannyloxazolidine 4. Grignard additions to the formyl group of compound 7 in the presence of Lewis acids afforded diastereomerically pure secondary carbinols 8. Protection of the hydroxyl group and unmasking of the oxazolidine ring gave O-protected α-hydroxy aldehydes 11, which were immediately reduced to the corresponding 1,2-diols 12.