357952-91-1

Upstream product

• 61475-31-8 (S)-hexahydromandelic acid 
• 223429-17-2 (S)-1-cyclohexyl-2-oxoethyl benzoate 
• 111902-61-5 (2R,3R)-3-cyclohexyl-2,3-epoxypropan-1-ol 
• 42134-55-4 (E)-3-cyclohexyl-2-propen-1-ol 
• 887605-51-8 (1S,2R)-1-cyclohexyl-2,3-dihydroxypropyl benzoate 
• 97531-43-6 2-cyclohexyl-2-oxoethyl 4-methylbenzenesulfonate 
• 61414-09-3 (S)-1-cyclohexyl-1,2-ethanediol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 3483-39-4 (S)-2-cyclohexyloxirane 
• 84619-58-9 (S)-(+)-1-amino-(1-cyclohexyl)ethanol 
• 887605-52-9 (R)-1-cyclohexyl-4-(trimethylsilyl)but-3-yn-1-ol 

Relevant academic research and scientific papers

The silylalkyne-prins cyclization: Stereoselective synthesis of tetra- and pentasubstituted halodihydropyrans

A new type of Prins cyclization using silylated secondary homopropargylic alcohols and aldehydes yielding tetra- and pentasubstituted dihydropyrans is described. The presence of the trimethylsilyl group in the triple bond favors the Prins cyclization and

Convenient synthesis of optically active 1,2-diol monosulfonates and terminal epoxides via oxazaborolidine-catalyzed asymmetric borane reduction of α-sulfonyloxy ketones

A very convenient asymmetric synthesis of 1,2-diol monosulfonates and terminal epoxides with high optical purity via oxazaborolidine-catalyzed asymmetric borane reduction of α-sulfonyloxy ketones using N-ethyl-N-isopropylaniline-borane complex as borane carrier has been developed.

Early transition metal alkoxide complexes bearing homochiral trialkanolamine ligands

Enantiomerically pure trialkanolamines of the formula N(CH2CHROH)3, where R = methyl (3a), cyclohexyl (3b), teri-butyl (3c), or phenyl (3d), are readily synthesized by the reaction of ammonia with 3 equiv of an enantiopure epoxide. Trialkanolamines 3a-d replace n-propanol in tri-n-propyl vanadate to afford corresponding complexes 4a-d of the formula LV=O, where L is the deprotonated trialkanolamine. Similarly, (S,S,S)-triisopropanolamine 3a reacts with Ti(OiPr)4 to produce monomeric LTi(OiPr), 7a, which upon treatment with acetyl chloride gives the chloro complex LTiCl, 7b. The later group 5 ethoxides react with 3a to produce LM(OEt)2 (M = Nb, Ta). Partial hydrolysis of the Nb and Ta derivatives produces tetrameric μ-oxo-bridged structures which retain the trialkanolamine ligands. In all complexes the transition metal resides in a highly asymmetric environment, suggesting that this class of complexes may find use in the field of asymmetric catalysis. The X-ray crystal structures of complexes 4c and 7b are reported.