22350-03-4

Usage

InChI:InChI=1/C13H16N2/c1-14-9-6-7-13-11(8-9)10-4-2-3-5-12(10)15-13/h2-5,9,14-15H,6-8H2,1H3

Upstream product

• 51145-61-0 1,2,3,4-tetrahydrocarbazol-3-one 
• 74-89-5 methylamine 
• 34154-31-9 3-hydroxy-1,2,3,4-tetrahydrocarbazole p-toluenesulphonate ester 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 100-63-0 phenylhydrazine 
• 166398-41-0 4-(N-methyl)aminocyclohexane ethylene acetal 

Downstream Products

• 844639-48-1 4-fluoro-N-methyl-N-(1,2,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide 
• 860475-40-7 3-{3-[(4-fluoro-benzenesulfonyl)-methyl-amino]-1,2,3,4-tetrahydro-carbazol-9-yl}-propionic acid ethyl ester 
• 1414848-11-5 tert-butyl N-methyl-[9-(3-(trifluoromethyl)phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]carbamate 
• 1414848-00-2 N-methyl-[9-(3-trifluoromethylphenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine 

Relevant academic research and scientific papers

N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists

The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT6 receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.

Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist

Ramatroban, a thromboxane A2 receptor (TP) antagonist with clinical efficacy in asthma and allergic rhinitis, was recently shown to also antagonize the prostaglandin D2 receptor CRTH2. Here we report that minor structural changes to

3-Hydroxy carbazole derivatives

3-(Substituted-amino)-1,2,3,4-tetrahydrocarbazoles are prepared by reacting appropriate 4-substituted-aminocyclohexanones with a phenylhydrazine, by reacting a 3-(sulfonyloxy)-1,2,3,4-tetrahydrocarbazole with an appropriate substituted amine, or by reduction of an appropriate 3-(acylamino)-1,2,3,4-tetrahydrocarbazole. The 3-(substituted-amino)-1,2,3,4-tetrahydrocarbazoles of this invention have analgetic and psychotropic activities. Moreover, certain of these compounds also have antihistaminic activity.

3-Amido-1,2,3,4-tetrahydrocarbazoles

3-(Substituted-amino)-1,2,3,4-tetrahydrocarbazoles are prepared by reacting appropriate 4-substituted-aminocyclohexanones with a phenylhydrazine, by reacting a 3-(sulfonyloxy)-1,2,3,4-tetrahydrocarbazole with an appropriate substituted amine, or by reduction of an appropriate 3-(acylamino)-1,2,3,4-tetrahydrocarbazole. The 3-(substituted-amino)-1,2,3,4-tetrahydrocarbazoles of this invention have analgetic and psychotropic activities. Moreover, certain of these compounds also have antihistaminic activity.