22350-03-4

Basic information

• Product Name: 3-methylamino-1,2,3,4-tetrahydrocarbazole
• Synonyms: 3-methylamino-1,2,3,4-tetrahydrocarbazole
• CAS NO: 22350-03-4
• Molecular Formula: C₁₃H₁₆N₂
• Molecular Weight: 0
• Mol File: 22350-03-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 365.8°Cat760mmHg
• Flash Point: 175°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 1.53E-05mmHg at 25°C
• Refractive Index: 1.639
• CAS DataBase Reference: 3-methylamino-1,2,3,4-tetrahydrocarbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methylamino-1,2,3,4-tetrahydrocarbazole(22350-03-4)
• EPA Substance Registry System: 3-methylamino-1,2,3,4-tetrahydrocarbazole(22350-03-4)

Safety Data

• Hazardous Substances Data: 22350-03-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H16N2/c1-14-9-6-7-13-11(8-9)10-4-2-3-5-12(10)15-13/h2-5,9,14-15H,6-8H2,1H3

Upstream product

• 100-63-0 phenylhydrazine 
• 166398-41-0 4-(N-methyl)aminocyclohexane ethylene acetal 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 34154-31-9 3-hydroxy-1,2,3,4-tetrahydrocarbazole p-toluenesulphonate ester 
• 51145-61-0 1,2,3,4-tetrahydrocarbazol-3-one 
• 74-89-5 methylamine 

Downstream Products

• 1414848-11-5 tert-butyl N-methyl-[9-(3-(trifluoromethyl)phenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]carbamate 
• 1414848-00-2 N-methyl-[9-(3-trifluoromethylphenylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amine 
• 860475-40-7 3-{3-[(4-fluoro-benzenesulfonyl)-methyl-amino]-1,2,3,4-tetrahydro-carbazol-9-yl}-propionic acid ethyl ester 
• 844639-48-1 4-fluoro-N-methyl-N-(1,2,4,9-tetrahydro-1H-carbazol-3-yl)benzenesulfonamide 

Relevant articles and documents

N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists

The design, synthesis and SAR of novel tetrahydrocarbazole derivatives having 5-HT6 receptor antagonist activity is presented. The racemic compound 15e was found to possess desirable pharmacokinetic properties, adequate brain penetration and activity in animal models of cognition.

3-Hydroxy carbazole derivatives

3-(Substituted-amino)-1,2,3,4-tetrahydrocarbazoles are prepared by reacting appropriate 4-substituted-aminocyclohexanones with a phenylhydrazine, by reacting a 3-(sulfonyloxy)-1,2,3,4-tetrahydrocarbazole with an appropriate substituted amine, or by reduction of an appropriate 3-(acylamino)-1,2,3,4-tetrahydrocarbazole. The 3-(substituted-amino)-1,2,3,4-tetrahydrocarbazoles of this invention have analgetic and psychotropic activities. Moreover, certain of these compounds also have antihistaminic activity.