223511-19-1

Basic information

• Product Name: 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-one
• Synonyms: 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-one
• CAS NO: 223511-19-1
• Molecular Weight: 336.506
• Mol File: 223511-19-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-one(223511-19-1)
• EPA Substance Registry System: 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-one(223511-19-1)

Safety Data

• Hazardous Substances Data: 223511-19-1(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 174362-59-5 C₁₉H₃₄O₃Si₂ 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 116585-12-7 2-((tert-butyldimethylsilyl)oxy)benzaldehyde 
• 642089-49-4 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-phenylprop-2-yn-1-ol 
• 827575-54-2 2-(tert-butyldimethylsilanyloxy)-benzoyl chloride 

Downstream Products

• 4970-21-2 2-(diphenylmethylene)benzofuranone 
• 1542081-32-2 1-[2-(tert-butyldimethylsilyloxy)phenyl]-3-mercapto-3-phenylprop-2-en-1-one 
• 582-04-7 aurone 
• 525-82-6 FLAVONE 
• 37542-14-6 aurone 

Relevant articles and documents

Synthesis of 1,3-thioxoketones from salicylaldehyde

A method for the synthesis of monothiodibenzoylmethanes was developed. The method involves a reaction of potassium thioacetate with 1-(2-hydroxyphenyl)-3- phenylpropynone prepared from salicylaldehyde.

Novel synthetic routes suitable for constructing benzopyrone combinatorial libraries

A series of O-(t-butylsilyloxy)benzoyl chlorides generated from the corresponding silyl esters were coupled with a range of terminal alkynes to afford the corresponding alkynyl ketones. The alkynyl ketones were converted to enaminoketones and then cyclized to yield the desired benzopyrone ring system. This synthetic protocol utilizes readily available starting materials, mild and high yielding reactions with good functional group tolerance, and is ideal for developing combinatorial libraries centered around the benzopyrone ring system.