223526-78-1

Basic information

• Product Name: ethyl 2-(4-methylphenylsulfonamido)benzoate
• Synonyms: ethyl 2-(4-methylphenylsulfonamido)benzoate
• CAS NO: 223526-78-1
• Molecular Weight: 319.381
• Mol File: 223526-78-1.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-methylphenylsulfonamido)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-methylphenylsulfonamido)benzoate(223526-78-1)
• EPA Substance Registry System: ethyl 2-(4-methylphenylsulfonamido)benzoate(223526-78-1)

Safety Data

• Hazardous Substances Data: 223526-78-1(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 87-25-2 2-ethoxycarbonylaniline 
• 65-85-0 benzoic acid 
• 941-55-9 4-toluenesulfonyl azide 
• 93-89-0 benzoic acid ethyl ester 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 

Downstream Products

• 932725-44-5 C₃₀H₃₂N₂O₅S₂ 
• 324057-41-2 2-{[(4-methylphenyl)sulfonyl](2-propen-1-yl)amino}benzoic acid 
• 223526-93-0 N-(2-hydroxymethylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide 
• 223526-79-2 N-(2-formylphenyl)-N-(2-propenyl)-4-toluenesulfonylamide 

Relevant articles and documents

An approach to the pyrroloquinoline core of martinelline and martinellic acid

An expedient method for the assembly of the pyrroloquinoline skeleton found in the martinelline alkaloids using a [3+2] cycloaddition of an azomethine ylide and an alkene has been developed.

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

Tandem Long Distance Chain-Walking/Cyclization via RuH2(CO)(PPh3)3/Br?nsted Acid Catalysis: Entry to Aromatic Oxazaheterocycles

A novel route to 1,3-oxazaheterocycles based on cooperative Ru-H/Br?nsted acid catalysis is reported. The use of the commercially available RuH2(CO)(PPh3)3 complex allows for an efficient long distance chain-walking process while the Br?nsted acid is responsible for generation of an electrophilic iminium ion which is trapped intramolecularly by an alcohol moiety. The alcohol, besides its nucleophilic function, also plays an important role in the stabilization of the Ru catalyst. (Chemical Equation Presented).

Iridium-catalyzed direct C-H amidation with weakly coordinating carbonyl directing groups under mild conditions

An iridium-catalyzed direct C-H amidation of weakly coordinating substrates, in particular of those bearing ester and ketone groups, under very mild conditions has been developed. The observed high reaction efficiency was achieved by the combined use of acetic acid and lithium carbonate as additives. Copyright

An intramolecular azomethine ylide-alkene cycloaddition approach to pyrrolo[3,2-c]quinolines-synthesis of a C2-truncated martinelline model

The hexahydropyrrolo[3,2-c]quinoline core found in the Martinella alkaloids was constructed through an intramolecular [3+2] azomethine ylide-alkene cycloaddition. Some chemical manipulations of the tricycle are reported.