223558-50-7Relevant academic research and scientific papers
Chemical determination of the absolute structures of resveratrol dimers, ampelopsins A, B, D and F
Takaya, Yoshiaki,Yan, Ke-Xu,Terashima, Kenji,Ito, Junko,Niwa, Masatake
, p. 7259 - 7265 (2002)
The absolute configurations of four stilbenedimers, (+)-ampelopsins A, (+)-ampelopsins B, (-)-ampelopsins D and (+)-ampelopsins F were respectively determined on the basis of chemical evidence.
Antifungal activity of resveratrol derivatives against Candida Species
Houillé, Benjamin,Papon, Nicolas,Boudesocque, Leslie,Bourdeaud, Eric,Besseau, Sébastien,Courdavault, Vincent,Enguehard-Gueiffier, Cécile,Delanoue, Guillaume,Guérin, Laurence,Bouchara, Jean-Philippe,Clastre, Marc,Giglioli-Guivarc'H, Nathalie,Guillard, Jér?me,Lanoue, Arnaud
, p. 1658 - 1662 (2014/08/18)
trans-Resveratrol (1a) is a phytoalexin produced by plants in response to infections by pathogens. Its potential activity against clinically relevant opportunistic fungal pathogens has previously been poorly investigated. Evaluated herein are the candidacidal activities of oligomers (2a, 3-5) of 1a purified from Vitis vinifera grape canes and several analogues (1b-1j) of 1a obtained through semisynthesis using methylation and acetylation. Moreover, trans-ε-viniferin (2a), a dimer of 1a, was also subjected to methylation (2b) and acetylation (2c) under nonselective conditions. Neither the natural oligomers of 1a (2a, 3-5) nor the derivatives of 2a were active against Candida albicans SC5314. However, the dimethoxy resveratrol derivatives 1d and 1e exhibited antifungal activity against C. albicans with minimum inhibitory concentration (MIC) values of 29-37 μg/mL and against 11 other Candida species. Compound 1e inhibited the yeast-to-hyphae morphogenetic transition of C. albicans at 14 μg/mL.
New oligostilbenes having a benzofuran from Vitis vinifera 'Kyohou'
Ito, Junko,Takaya, Yoshiaki,Oshima, Yoshiteru,Niwa, Masatake
, p. 2529 - 2544 (2007/10/03)
Three new oligostilbenes having a benzofuran moiety, viniferifuran, (+)- vitisifuran A and (-)-vitisifuran B, were isolated from Vitis vinifera 'Kyohou'. The structures of these oligostilbenes including the absolute configuration were elucidated by spectroscopic and chemical methods. Furthermore, these were chemically transformed from (+)-ε-viniferin, (+)- vitisin A and (-)-vitisin B, respectively, whose absolute configurations are known.
Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives
Ohyama, Masayoshi,Tanaka, Toshiyuki,Ito, Tetsuro,Iinuma, Munekazu,Bastow, Kenneth F.,Lee, Kuo-Hsiung
, p. 3057 - 3060 (2007/10/03)
Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values
