223787-61-9

Basic information

• Product Name: N-{2-[2-(2-bromo-4-chloro-phenyl)-ethyl]-5-chloro-phenyl}-formamide
• Synonyms: N-{2-[2-(2-bromo-4-chloro-phenyl)-ethyl]-5-chloro-phenyl}-formamide
• CAS NO: 223787-61-9
• Molecular Weight: 373.076
• Mol File: 223787-61-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-{2-[2-(2-bromo-4-chloro-phenyl)-ethyl]-5-chloro-phenyl}-formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-[2-(2-bromo-4-chloro-phenyl)-ethyl]-5-chloro-phenyl}-formamide(223787-61-9)
• EPA Substance Registry System: N-{2-[2-(2-bromo-4-chloro-phenyl)-ethyl]-5-chloro-phenyl}-formamide(223787-61-9)

Safety Data

• Hazardous Substances Data: 223787-61-9(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 223787-55-1 2-[2-(2-bromo-4-chloro-phenyl)-ethyl]-5-chloro-phenylamine 
• 89-59-8 4-chloro-2-nitrotoluene 
• 32989-56-3 4-chloro-1-[(2-dimethylamino)ethenyl]-2-nitrobenzene 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 223787-50-6 C₁₄H₈BrCl₂NO₂ 
• 141-53-7 sodium formate 
• 223787-50-6 C₁₄H₈BrCl₂NO₂ 
• 78347-96-3 diethyl <(2-bromo-4-chlorophenyl)methyl>phosphonate 
• 27139-97-5 2-bromo-4-chloro-1-methyl-benzene 

Downstream Products

• 13080-74-5 3,7-Dichloro-10,11-dihydro-5H-dibenz[b,f]azepine 

Relevant articles and documents

A depression drug impurity of preparing method (by machine translation)

The invention relates to a depression drug impurity of preparing method, it comprises the following steps: (a) the high sodium iodate, water and mixed DMF; (b) is poured into ice water, adjusting pH with alkali and layered extraction, purification to obtain compound 4; in the 120 - 150 °C reaction after column chromatography separation to obtain compound 5; (c) the compound 3 and said compound 5 by adding ethylene glycol dimethyl ether, in the ice water bath under the conditions of the adding sodium hydride to, heating up to 40 - 60 °C reaction 20 - 40 minutes, further heating up to reflux; (d) the compound 6 with the [...] catalyst, morpholine, methanol and ethanol are mixed, the reaction is carried out in a hydrogen atmosphere, filtered [...] filtrate to obtain compound 7; (e) the compound 7 with formic acid, a sodium mixed, heated to 100 - 120 °C refluxing reaction; (g) the compound 10 in toluene soluble, in an inert gas atmosphere by adding sodium hydride, temperature reaction. This can obtain the high purity of the depression drug impurity isomer, for impurity accurate control. (by machine translation)

Preparation method of impurity isomer key intermediate of anti-depressive drug

The invention relates to a preparation method of an impurity isomer key intermediate of an anti-depressive drug. The preparation method comprises the following steps: (a) mixing sodium periodate, water and DMF (Dimethylformamide); (b) pouring in ice water, adjusting pH with an alkaline solution, extracting by layers, purifying to obtain a compound 4, and performing column chromatography isolationafter reacting at 120 to 150 DEG C to obtain a compound 5; (c) adding the compound 3 and the compound 5 into 1,2-dimethoxyethane, adding sodium hydride under the condition of ice water bath, heating to 40 to 60 DEG C for reacting for 20 to 40 minutes, and heating and refluxing; (d) mixing the compound 6 with a rhodium carbon catalyst, morpholine, methanol and ethanol, reacting under a hydrogen atmosphere, and performing suction filtration and spin drying on filtrate to obtain a compound 7; (e) mixing the compound 7 with formic acid and sodium formate, and heating to 100 to 120 DEG C for refluxreaction; (f) adding anhydrous K2CO3,Cu powder and CuBr, performing reaction under the protection of insert gas at the temperature of 150 to 180 DEG C to obtain a compound 9; cooling to 30 to 60 DEGC, adding NaOH solution to perform reaction, filtering, and purfying to obtain a compound 10.. By adopting the preparation method, a high-purity impurity isomer of the anti-depressive drug can be obtained for accurate control of impurities.