223913-42-6

Basic information

• Product Name: (2R,3S)-3-amino-2,4-diphenylbutan-2-ol
• Synonyms: (2R,3S)-3-amino-2,4-diphenylbutan-2-ol
• CAS NO: 223913-42-6
• Molecular Weight: 241.333
• Mol File: 223913-42-6.mol

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-amino-2,4-diphenylbutan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-amino-2,4-diphenylbutan-2-ol(223913-42-6)
• EPA Substance Registry System: (2R,3S)-3-amino-2,4-diphenylbutan-2-ol(223913-42-6)

Safety Data

• Hazardous Substances Data: 223913-42-6(Hazardous Substances Data)

Upstream product

• 5619-07-8 methyl 2-amino-3-phenylpropanoate hydrochloride 
• 100-52-7 benzaldehyde 
• 131150-38-4 (S)-3-Dibenzylamino-4-phenyl-butan-2-one 
• 223913-37-9 (2R,3S)-3-Dibenzylamino-2,4-diphenyl-butan-2-ol 
• 591-51-5 phenyllithium 

Relevant articles and documents

Kinetic Resolution of Tertiary 2-Alkoxycarboxamido-Substituted Allylic Alcohols by Chiral Phosphoric Acid Catalyzed Intramolecular Transesterification

A highly enantioselective kinetic resolution of tertiary 2-alkoxycarboxamido allylic alcohols has been achieved through a chiral phosphoric acid catalyzed intramolecular transesterification reaction. Both alkyl,aryl- and dialkyl-substituted tertiary allylic alcohols were resolved with excellent efficiencies, affording both the recovered tertiary alcohols and the carbamate products with high enantioselectivities (with s factors up to 164.6). A gram-scale reaction with 1 mol % catalyst loading and the facile conversion of the enantioenriched products into useful chiral building blocks, such as chiral oxazolidinones and β-amino alcohols, demonstrate the value of this reaction.

Stereoselective Grignard-type reactions of chiral N,N-dibenzylamino ketones

N,N-Dibenzylamino ketones of the type Bn2N(R1)CHC(O)R2, prepared in enantiomerically pure form from α-amino acids, undergo non-chelation controlled Grignard-type reactions with RLi, RMgX or RCeCl2 without any un