22396-75-4

Basic information

• Product Name: 4-methoxy-N,N-dimethylbut-2-yn-1-amine
• CAS NO: 22396-75-4
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.1842
• Mol File: 22396-75-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 168.3°C at 760 mmHg
• Flash Point: 45.9°C
• Density: 0.901g/cm³
• Vapor Pressure: 1.63mmHg at 25°C
• Refractive Index: 1.45
• CAS DataBase Reference: 4-methoxy-N,N-dimethylbut-2-yn-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxy-N,N-dimethylbut-2-yn-1-amine(22396-75-4)
• EPA Substance Registry System: 4-methoxy-N,N-dimethylbut-2-yn-1-amine(22396-75-4)

Safety Data

• Hazardous Substances Data: 22396-75-4(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 
• 627-41-8 propargyl alcohol methyl ether 
• 14002-21-2 dimethylaminomethanol 

Downstream Products

• 73586-40-0 N,N-dimethyl-2-benzyl-2,3-butadienylamine 

Relevant articles and documents

Grignard Addition Reactions to 1,4-Difunctionalized But-2-ynes

Trisubstituted alkenes of E geometry have been prepared by anti addition of Grignard reagents to 1,4-difunctionalized but-2-ynes.Addition of primary, secondary and aromatic Grignard reagents to but-2-yne-1,4-diol provided (E)-2-substituted but-2-ene-1,4-diols as major products along with the corresponding 2-substituted buta-2,3-dien-1-ols.Addition of phenylmagnesium bromide to the mono- and di-methyl ethers of but-2-yne-1,4-diol gave 2,3-diphenyl-1,3-diene.Treatment of 4-dimethylaminobut-2-yn-1-ol with primary alkyl and alkenyl Grignard reagents afforded the 2-substituted anti addition product regiospecifically, stereospecifically and in high yield.Reaction of 1-dimethylamino-4-methoxybut-2-yne with butylmagnesium bromide provided only the 3-substituted anti addition product in good yield.