2242-31-1

Usage

Uses

Used in Organic Synthesis:
1,4-Benzodioxan-2-methylamine, N-methylis used as a building block in organic synthesis for the creation of various pharmaceuticals and research chemicals. Its unique structure allows for the development of new compounds with potential therapeutic properties.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1,4-Benzodioxan-2-methylamine, N-methylserves as a key intermediate in the synthesis of drugs. Its incorporation into drug molecules can enhance their pharmacological activity and selectivity.
Used in Neuroscience Research:
Due to its structural resemblance to neurotransmitters and psychoactive compounds, 1,4-Benzodioxan-2-methylamine, N-methylmay be used in neuroscience research to study the interactions of these compounds with biological systems and to develop new treatments for neurological disorders.
Used in Pharmacology:
In pharmacology, 1,4-Benzodioxan-2-methylamine, N-methylcould be employed to investigate the mechanisms of action of psychoactive substances and to design new drugs with improved efficacy and safety profiles.

InChI:InChI=1/C10H13NO2/c1-11-6-8-7-12-9-4-2-3-5-10(9)13-8/h2-5,8,11H,6-7H2,1H3

Upstream product

• 2164-33-2 2-chloromethyl-1,4-benzodioxane 
• 74-89-5 methylamine 
• 21398-80-1 N-methyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide 
• 4442-59-5 (2,3-dihydrobenzo[1,4]dioxin-2-ylmethyl)amine 
• 871824-54-3 N-((2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl)formamide 
• 4739-94-0 ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate 

Downstream Products

• 102128-83-6 N-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-N-methyl-β-alanine-methylamide 
• 102128-80-3 N-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-N-methyl-β-alanine-diethylamide 
• 102128-81-4 N-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-N-methyl-β-alanine-dimethylamide 
• 73120-83-9 N-Methyl-N-(2-hydroxyethyl)(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine 
• 114043-44-6 N-(Cyclohexyl-phenyl-methyl)-2-[(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-acetamide 
• 119746-86-0 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethyl} ester 5-methyl ester 
• 112358-09-5 2-amino>ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 119746-87-1 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-1-methyl-ethyl} ester 5-methyl ester 
• 119746-89-3 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-{2-[(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethyl} ester 5-isopropyl ester 
• 119746-93-9 1-Methyl-2-amino>ethyl isopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant academic research and scientific papers

Novel, broad-spectrum anticonvulsants containing a sulfamide group: Pharmacological properties of (S)- N -[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2- yl)methyl]sulfamide (JNJ-26489112)

Broad-spectrum anticonvulsants are of considerable interest as antiepileptic drugs, especially because of their potential for treating refractory patients. Such "neurostabilizers" have also been used to treat other neurological disorders, including migraine, bipolar disorder, and neuropathic pain. We synthesized a series of sulfamide derivatives (4-9, 10a-i, 11a, 11b, 12) and evaluated their anticonvulsant activity. Thus, we identified promising sulfamide 4 (JNJ-26489112) and explored its pharmacological properties. Compound 4 exhibited excellent anticonvulsant activity in rodents against audiogenic, electrically induced, and chemically induced seizures. Mechanistically, 4 inhibited voltage-gated Na+ channels and N-type Ca2+ channels and was effective as a K+ channel opener. The anticonvulsant profile of 4 suggests that it may be useful for treating multiple forms of epilepsy (generalized tonic-clonic, complex partial, absence seizures), including refractory (or pharmacoresistant) epilepsy, at dose levels that confer a good safety margin. On the basis of its pharmacology and other favorable characteristics, 4 was advanced into human clinical studies.

USE OF BENZO-FUSED HETEROCYLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF ANXIETY

The present invention is a method for the treatment of anxiety and related disorders comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I)

USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN

The present invention is a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as desc

USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR DISEASE MODIFICATION / EPILEPTOGENESIS

The present invention is a method for treating, preventing, reversing, arresting or inhibiting the occurrence, development and maturation of seizures or seizure-related disorders. More specifically, the present invention is directed to methods for the use

CO-THERAPY FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS

The present invention is directed to co-therapy for the treatment of epilepsy and related disorders comprising administering to a subject in need thereof, co-therapy with a therapeutically effective amount of a benzo-fused heterocycle sulfamide derivative

USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR LOWERING LIPIDS AND LOWERING BLOOD GLUCOSE LEVELS

The present invention is a method for the glucose related disorders and lipid related disorders comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of

USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES AS NEUROPROTECTIVE AGENTS

The present invention is a methods for neuroprotection, for treating an acute neurodegenerative disorder, for treating a chronic neurodegenerative disorder and/or for preventing neuron death or damage following brain, head and/or spinal cord trauma or inj

USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF SUBSTANCE ABUSE AND ADDICTION

The present invention is a method for the treatment of alcohol abuse and/or addiction comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I

USE OF BENZO-FUSED HETEROCYLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MANIA AND BIPOLAR DISORDER

The present invention is a method for the treatment of mania and/or bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I)

USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF DEPRESSION

The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) a