22426-91-1

Basic information

• Product Name: Benzamide, 4-chloro-N-(phenylmethoxy)-
• CAS NO: 22426-91-1
• Molecular Formula: C14H12ClNO2
• Molecular Weight: 261.708
• Mol File: 22426-91-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-chloro-N-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-chloro-N-(phenylmethoxy)-(22426-91-1)
• EPA Substance Registry System: Benzamide, 4-chloro-N-(phenylmethoxy)-(22426-91-1)

Safety Data

• Hazardous Substances Data: 22426-91-1(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 57139-20-5 potassium p-chlorobenzohydroxyamate 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 122-01-0 4-chloro-benzoyl chloride 
• 74-11-3 para-chlorobenzoic acid 
• 622-33-3 N-benzyloxyamine 
• 450408-66-9 4,5-dichloro-2-(4-chloro-benzoyl)-2H-pyridazin-3-one 

Downstream Products

• 1613-88-3 4-chloro-N-hydroxybenzamide 
• 1392108-26-7 O-benzyl-N-(4-chlorobenzoyl)-N-phenylhydroxylamine 
• 67483-73-2 benzyl p-chlorobenzoate 

Relevant articles and documents

A metal-free iodine-mediated conversion of hydroxamates to esters

A metal-, oxidant-, and additive-free conversion of hydroxamates to esters have been achieved using molecular iodine as the reagent using a novel but not-so-explored heron-type rearrangement. The reaction proceeds with almost equal facility with substrates having either electron-donating or electron-withdrawing substituent. Similarly, α,?-unsaturated, and sterically hindered ortho-substituted hydroxamates also undergo the desired transformation smoothly.

Syntheses and evaluation of substituted aromatic hydroxamates and hydroxamic acids that target Mycobacterium tuberculosis

Tuberculosis (TB) continues to remain one of the most threatening diseases in the world. With the emergence of multi-drug resistant (MDR) and extensively drug resistant (XDR) strains, the need to develop new therapies is dire. The syntheses of a focused library of hydroxamates and hydroxamic acids is described, as well as anti-TB activity in the microplate alamar blue assay (MABA). A number of compounds exhibited good activity against Mtb, with notable compounds exhibiting MIC values in the range of 20-0.71 μM. This work suggests that both hydroxamates and their free acids may be incorporated into more complex scaffolds and serve as potential leads for the development of anti-TB agents.

Design, synthesis and utilization of a novel coupling reagent for the preparation of O-alkyl hydroxamic acids

An efficient novel reagent, phosphoric acid diethyl ester 2-phenyl-benzimidazol-1-yl ester, was designed, and synthesized and its applicability was demonstrated for the preparation of O-alkyl hydroxamic acids. The O-alkyl hydroxamic acids of N-protected a