22438-39-7Relevant articles and documents
Synthetic method of 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide
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Paragraph 0030-0032; 0037-0039, (2019/01/21)
The invention discloses a synthetic method of 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide, comprising the following steps: firstly mixing 1-bromo-n-decane and sodium methyl mercaptide, addingtetrabutylammonium bromide and carrying out a reaction, and conducting aftertreatment on the reaction product so as to obtain n-decyl methyl sulfide; dissolving n-decyl methyl sulfide and dimethyl sulfate in a solvent I, and carrying out a heating reflux reaction; carrying out reduced pressure distillation of the solvent I after the reaction so as to obtain a reaction product containing sulfoniumsalt; carrying out an epoxidation reaction by successively adding the reaction product containing sulfonium salt, sodium hydroxide and 2,4'-difluorobenzophenone into a solvent II, and carrying out aftertreatment after the reaction so as to obtain 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide. By the method for synthesizing 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide, the invention has technical advantages of environmental protection, high yield and the like.
Sulfonium salt type chloramine antibacterial agent and synthetic method thereof
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Paragraph 0047; 0048, (2018/11/22)
The invention belongs to the technical field of chemical synthesis and application of chloramine antibacterial agents, and provides a sulfonium salt type chloramine antibacterial agent and a syntheticmethod thereof. A preparation method of the antibacterial agent comprises the following steps: taking bromoalkyl 5,5-dimethylhydantoin and thioether as raw materials to prepare a sulfonium salt bromide chloramine precursor compound IV; reacting the precursor compound IV with t-butyl hypochlorite at normal temperature after ion exchange to obtain an antibacterial agent compound I. The antibacterial agent disclosed by the invention introduces a cationic structural unit-sulfonium salt group into a hydrophobic chain chloramine group, so that water solubility of the chloramine antibacterial agentis greatly improved and structure stability of the chloramine antibacterial agent is significantly enhanced. By using staphylococcus aureus as a model strain, the antibacterial test result shows thatthe bactericidal activity of the prepared sulfonium salt type chloramine compound is better than that of a mono-quaternary ammonium salt type chloramine compound.
Methyl transfers. 14. Nucleophilic catalysis of nucleophilic substitution
McCortney,Jacobson,Vreeke,Lewis
, p. 3554 - 3559 (2007/10/02)
Nucleophiles X- can catalyze the substitution Nu- + RY → NuR + Y- by adding the faster pathway X- + RY → XR + Y- followed by Nu- + XR → RNu + X-. New examples include catalysis by I- of the exchange of methyl between two dialkyl sulfides and the transfer of methyl from an arsonium salt to a phosphine. The individual reactions are separately studied and some equilibrium information is presented. Iodide is ineffective in the transfer of methyl between two pnosphines, which is not detected with or without iodide. The Marcus equation treatment of this catalysis is shown to require that the identity transfer of R between two X- groups be far faster than that for transfer of R between two Nu- groups. Nucleophiles other than I- are discussed. The possibility that some "supernucleophiles" may have fast identity rates is discussed, and literature evidence that this is indeed the case is presented. Stereochemical studies using chiral methyl derivatives have shown that vitamin B12 does provide a nucleophilic catalysis to methyl transfer in living systems. Thus, the apparently superfluous participation of B12 in some biological methyl transfers is explained.