88374-05-4

Basic information

• Product Name: 2-(2-FLUOROPHENYL)-2-(4-FLUOROPHENYL)OXIRANE [FOR FLUTRIAFOL]
• Synonyms: 2-(2-FLUOROPHENYL)-2-(4-FLUOROPHENYL)OXIRANE [FOR FLUTRIAFOL];Oxirane,2-(2-fluorophenyl)-2-(4-fluorophenyl)-
• CAS NO: 88374-05-4
• Molecular Formula: C14H10F2O
• Molecular Weight: 232.23
• Mol File: 88374-05-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-FLUOROPHENYL)-2-(4-FLUOROPHENYL)OXIRANE [FOR FLUTRIAFOL](CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FLUOROPHENYL)-2-(4-FLUOROPHENYL)OXIRANE [FOR FLUTRIAFOL](88374-05-4)
• EPA Substance Registry System: 2-(2-FLUOROPHENYL)-2-(4-FLUOROPHENYL)OXIRANE [FOR FLUTRIAFOL](88374-05-4)

Safety Data

• Hazardous Substances Data: 88374-05-4(Hazardous Substances Data)

Usage

General Description

2-(2-Fluorophenyl)-2-(4-fluorophenyl)oxirane, also known as flutriafol, is a chemical compound commonly found in fungicides used in agriculture. It is a member of the triazole family of chemicals and is known for its ability to effectively control a wide range of fungal diseases in crops. Flutriafol works by inhibiting the production of ergosterol, a crucial component of the fungal cell membrane, ultimately disrupting the growth and development of the fungi. 2-(2-FLUOROPHENYL)-2-(4-FLUOROPHENYL)OXIRANE [FOR FLUTRIAFOL] has been proven to be effective in controlling diseases in various crops, including cereals, fruits, and vegetables, making it a valuable tool for farmers in their efforts to protect their crops from fungal infections and maximize their yields.

Upstream product

• 22438-39-7 1-(methylthio)decane 
• 342-25-6 2,4'-difluorobenzophenone 
• 77-78-1 dimethyl sulfate 
• 3698-95-1 methyl octyl sulfide 
• 74-88-4 methyl iodide 
• 74-87-3 methylene chloride 
• 1765-93-1 4-fluoroboronic acid 
• 1813-93-0 ethyl 2-(2-fluorophenyl)-2-oxoacetate 
• 1053246-11-9 (S)-1-(2-fluorophenyl)-1-(4-fluorophenyl)ethane-1,2-diol 
• 1053246-12-0 toluene-4-sulfonic acid (S)-2-(2-fluorophenyl)-2-(4-fluorophenyl)-2-hydroxyethyl ester 

Relevant articles and documents

Synthetic method of 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide

The invention discloses a synthetic method of 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide, comprising the following steps: firstly mixing 1-bromo-n-decane and sodium methyl mercaptide, addingtetrabutylammonium bromide and carrying out a reaction, and conducting aftertreatment on the reaction product so as to obtain n-decyl methyl sulfide; dissolving n-decyl methyl sulfide and dimethyl sulfate in a solvent I, and carrying out a heating reflux reaction; carrying out reduced pressure distillation of the solvent I after the reaction so as to obtain a reaction product containing sulfoniumsalt; carrying out an epoxidation reaction by successively adding the reaction product containing sulfonium salt, sodium hydroxide and 2,4'-difluorobenzophenone into a solvent II, and carrying out aftertreatment after the reaction so as to obtain 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide. By the method for synthesizing 1-(2-fluorophenyl)-1-(4-fluorophenyl)ethylene oxide, the invention has technical advantages of environmental protection, high yield and the like.

A synthesis method of flutriafol (by machine translation)

The invention relates to a synthesis method of flutriafol, the halogenated methane and dimethyl sulfoxide in the 0 - 120 °C reaction under 1 - 48 H-; adding solid alkali and 2, 4' - difluoro benzophenone, temperature control in the 0 - 80 °C, reaction 1 - 25 the H; adding triazole, temperature control in the 50 - 200 °C, reaction 1 - 20 the H, after the reaction, filtered, to remove solvent, washing, crystallization get said teflubenzuron. In the present invention dimethyl sulfoxide is used as the reaction raw material, but also as the solvent, avoiding mixed solvent separation difficulties, and, dimethyl sulfoxide and halogenated methane to replace the existing technology to the environment in the pressure of the dimethyl sulfide and highly toxic chemicals dimethyl sulfate, so that the present invention is friendly to the environment, in addition, the invention mild reaction conditions, the reaction time is short, high yield, high product quality, three waste emissions low, produces only a sole inorganic salt, of the present invention thereby the productivity is high, economic efficiency is good. (by machine translation)

Stereoselective synthesis of (+)-flutriafol

The stereoselective synthesis of (+)-flutriafol, a triazole fungicide, has been accomplished in seven linear steps from (1S)-[(4R)-2,2-dimethyl-[1,3]-dioxolan-4-yl]-(4-methoxyphenyl)methanol in 15% overall yield. Diastereoselective nucleophilic 1,2-addition was employed as a key step for constructing the requisite chiral 1,2-diol for flutriafol. A high degree of 1,4-asymmetric induction could be realized via a chelation-controlled mechanism during the key alkylation step.