22454-54-2Relevant academic research and scientific papers
Stereoselective, solvent free, highly efficient synthesis of aldo- and keto-: N -acylhydrazones applying grindstone chemistry
Dos Santos Filho, José Maurício,Pinheiro, Savio Moita
supporting information, p. 2212 - 2224 (2017/07/24)
A mild and efficient synthesis of N-acylhydrazones has been developed, applying a simple grindstone procedure, leading to a library of 51 examples exhibiting a broad variety of structural features, 21 of them described for the first time in this paper. Th
Mild, Stereoselective, and Highly Efficient Synthesis of N-Acylhydrazones Mediated by CeCl3·7H2O in a Broad Range of Solvents
Dos Santos Filho, José Maurício
supporting information, p. 6411 - 6417 (2016/02/18)
In a mild and practical approach, hydrazides and aldehydes underwent condensation reactions that were mediated by cerium(III) chloride to be rapidly converted into N-acylhydrazones. This method uses a minimal catalytic amount of cerium(III), is stereosele
Synthesis, oxidation and dehydrogenation of cyclic N,O- and N,S-acetals. Part III. [1,2] Transformation of N,O-acetals: 3-Acyl-1,3,4-oxadiazolines
Somogyi, Laszlo
, p. 1235 - 1246 (2008/09/18)
(Chemical Equation Presented) Various aldehyde and ketone acylhydrazones are synthesized and, under acylating conditions, cyclized into 3-acyl-1,3,4-oxadiazolines. The scope and limitations of these cyclizations and the possible side reactions (e.g. formation of the open-chain N,O-acylhydrazinocarbinols) are dissected. For the first time, simple, convenient and efficient dehydrogenations of 3-acyl-1,3,4-oxadiazolines to oxadiazoles by treatment with potassium permanganate, or more conveniently, with ammonium cerium(IV) nitrate (CAN) are presented. CAN oxidation of 2,2-disubstituted 3-acyl-1,3,4-oxadiazolines, as well as that of aldehyde diacylhydrazones (open-chain isomers of 2,5-disubstituted 3-acyl-1,3,4- oxadiazolines) regenerates the parent carbonyl compounds.
Antihypertensive actions of hydrazidones: Study of acylated dichloroarylhydrazones
Cave,Galons,Miocque,Rinjard,Tran,Binet
, p. 75 - 79 (2007/10/02)
A series of acylated dichloroarylhydrazones has been prepared and evaluated on spontaneously hypertensive rats (SHR). The presence of 2-Cl and 6-Cl aromatic substituents in a clonidine like position is not required since derivatives bearing 2- and 4-chloro as well as 3- and 4-chloro substituents exert antihypertensive activities. Activity is also maintained in certain 2,6 disubstituted derivatives where one of the chlorine atoms is replaced by F or NO2.
