22456-89-9Relevant articles and documents
Prochiral Diheteroaryl Sulfoxides and Their Reactions with (S)-Li2-BINOLate-Activated Diisobutylmagnesium
Ruppenthal, Simon,Brückner, Reinhard
, p. 89 - 98 (2018)
5-Membered ring heterocycles were α-lithiated or α-magnesiated so that they attacked SOCl2 or SO(OMe)2 forming symmetric – i.e. prochiral – diheteroaryl sulfoxides. The latter were treated with a 0.5- or 1.2-fold molar amount of 5:4 mixtures of dilithium (S)-BINOLate and diisobutylmagnesium. This allowed five asymmetric sulfoxide/magnesium exchange reactions to occur. They delivered asymmetric sulfoxides in up to 77 % yield and with up to 88 % ee. Surprisingly, four related diheteroaryl sulfoxides, bis(2-pyridyl) sulfoxide, and bis(3-pyridyl) sulfoxide were unamenable to such exchanges and decomposed instead.
Design, synthesis and antiplasmodial evaluation of sulfoximine-triazole hybrids as potential antimalarial prototypes
Mabasa, Tommy Fredrick,Awe, Babatunde,Laming, Dustin,Kinfe, Henok Hadgu
, p. 683 - 690 (2019/08/30)
Background: Malaria, caused by the deadly Plasmodium falciparum strain, claims the lives of millions of people annually. The emergence of drug-resistant strains of P. falciparum to the artemisinin-based combination therapy (ACT), the last line of defense against malaria, is worrisome and urges for the development of new chemo-types with a new mode of action. In the search of new antimalarial agents, hybrids of triazoles and other known antimalarial drugs have been reported to possess better activity than either of the parent compounds administered individually. Despite their better activity, no hybrid antimalarial drugs have been developed so far. Objective: In the hope of developing new antimalarial prototypes, we propose the design, synthesis and antimalarial evaluation of novel sulfoximine-triazole hybrids owing to their interesting biological and physiological properties. Method: The sulfoximine part of the hybrid will be synthesized via imidation of the corresponding sulfoxide. Propargylation of the NH moiety of the sulfoximine followed by copper-catalyzed click chemistry with benzyl azide was envisaged to provide the target sulfoximine-triazole hybrids. Results: Five novel sulfoximine-triazole hybrids possessing various substituents on the sulfoximine moiety have been successfully synthesized and evaluated for their antiplasmodial and cytotoxicity activities. The results revealed that the co-presence of the sulfoximine and triazole moieties along with a lipophilic alkyl substituent on the sulfur atom impart significant activity. Conclusion: Sulfoximine-triazole hybrids could be used as a prototype for the synthesis of new derivatives with better antiplasmodial activities.
Diastereoconvergent synthesis of trans -5-hydroxy-6-substituted-2- piperidinones by addition-cyclization-deprotection process
Si, Chang-Mei,Huang, Wei,Du, Zhen-Ting,Wei, Bang-Guo,Lin, Guo-Qiang
, p. 4328 - 4331 (2014/09/30)
A diastereoselective one-pot approach to access trans-5-hydroxy-6- substituted-2-piperidinones by an addition-cyclization-deprotection process has been developed, in which the stereogenic center at the C-6 position was solely controlled by α-OTBS group. The utility of this transformation is demonstrated by the asymmetric synthesis of the enantiomer of (-)-CP-99,994.
