Tetrahedron Letters p. 2279 - 2282 (1999)
Update date:2022-08-03
Topics:
Eng, Hugo M.
Myles, David C.
In the preceding letter, we described a synthesis of the conserved C.1- C.13 hydrophobic domain common to the potent B-type amphidinolides. In this letter, we present syntheses of the C.14-C.26 hydrophilic domain specific to amphidinolide B1 and a model for uniting the hydrophobic and hydrophilic domains to form the (E)-1,1',3-trisubstituted diene.
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Doi:10.1002/chem.201603941
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