22479-76-1

Basic information

• Product Name: 1-METHOXY-3-(4-NITROPHENOXY) BENZENE
• Synonyms: 1-METHOXY-3-(4-NITROPHENOXY) BENZENE
• CAS NO: 22479-76-1
• Molecular Formula: C₁₃H₁₁NO₄
• Molecular Weight: 245.23074
• Mol File: 22479-76-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 358.7°C at 760 mmHg
• Flash Point: 154.7°C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 5.15E-05mmHg at 25°C
• Refractive Index: 1.588
• CAS DataBase Reference: 1-METHOXY-3-(4-NITROPHENOXY) BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHOXY-3-(4-NITROPHENOXY) BENZENE(22479-76-1)
• EPA Substance Registry System: 1-METHOXY-3-(4-NITROPHENOXY) BENZENE(22479-76-1)

Safety Data

• Hazardous Substances Data: 22479-76-1(Hazardous Substances Data)

Usage

Physical state

Pale yellow solid at room temperature.

Usage

Intermediate in the synthesis of pharmaceuticals, pesticides, and perfumes.

Properties

Antifungal and antimicrobial.

Applications

Ingredient in personal care and cosmetic products, flavoring agent in food and beverages.

Safety concerns

Potential health hazards, such as skin and eye irritation.

Reactivity

Reacts with oxidizing agents.

Handling precautions

Handle with caution due to potential health hazards and reactivity.

InChI:InChI=1/C13H11NO4/c1-17-12-3-2-4-13(9-12)18-11-7-5-10(6-8-11)14(15)16/h2-9H,1H3

Upstream product

• 100-02-7 4-nitro-phenol 
• 217813-03-1 3-methoxy-2-(trimethylsilyl)phenyl-trifluoromethanesulfonate 
• 586-78-7 para-nitrophenyl bromide 
• 100-00-5 4-chlorobenzonitrile 
• 150-19-6 O-methylresorcine 
• 350-46-9 4-Fluoronitrobenzene 
• 52688-74-1 potassium 3-methoxyphenolate 
• 22483-31-4 3-(4-Nitrophenoxy)phenol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 56705-86-3 4-(3-methoxyphenoxy)aniline 
• 22483-31-4 3-(4-Nitrophenoxy)phenol 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY

The present invention provides a novel heterocyclic compound represented by Formula [I] and a salt thereof: wherein the symbols are as defined in the specification, which is useful for treating, preventing and/or diagnosing seizure and the like in disease involving epileptic seizure or convulsive seizure (including multiple drug resistant seizure, refractory seizure, acute symptomatic seizure, febrile seizure and status epilepticus), as well as a medical use therefor.

Derivatives of quinoline as inhibitors for MEK

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof. wherein: n is 0-1; X and Y are independently selected from -NH-, -O-, -S-, or -NR8- where R8 is alkyl of 1-6 carbon atoms and X may additionally comprise a CH2 group; R7 is a group (CH2)mR9 where m is 0,or an integer of from 1-3 and R9 is a substituted aryl group, an optionally substituted cycloalkyl ring of up to 10 carbon atoms, or an optionally substituted heterocyclic ring or an N-oxide of any nitrogen containing ring; R6 is a divalent cycloalkyl of 3 to 7 carbon atoms, which may be optionally further substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a divalent pyridinyl, pyimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally further substituted with one or more specified groups; R1, R2, R3 and R4 are each independently selected from hydrogen or various specified organic groups. Compounds are useful as pharmaceuticals for the inhibition of MEK activity.

Facile O-Arylation of Phenols and Carboxylic Acids

(Equation presented) A facile, transition-metal-free O-arylation procedure for phenols and aromatic carboxylic acids has been developed that affords good to excellent yields of arylated products under very mild reaction conditions. A methoxy-substituted aryl triflate affords O-arylated products in high yields with excellent regioselectivity. This chemistry tolerates a variety of functional groups.