22485-02-5Relevant academic research and scientific papers
FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY
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Page/Page column 221; 222, (2019/03/17)
A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.
PRODRUGS OF GABA ANALOGS
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Paragraph 00212-00214, (2013/03/26)
The disclosures herein provide compounds of formula ?, formula II, formula 111 and formula IV or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers, and hydrates thereof. These salts may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for oral administration, transdermal administration, transmucosal, syrups, topical, extended or sustained release, or injection. Such compositions may be used to treatment of neurological disease and conditions such as neuropathic pain, diabetic neuropathic pain, epilepsy, restless leg syndrome, and other diseases related sub-chronic and chronic pain or its associated complications.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROPATHIC PAIN
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Paragraph 00128; 00129, (2013/12/03)
The invention relates to the compounds of formula (I), formula (II), formula (III) and formula (IV) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), formula (II), formula (III) or formula (IV) and methods for the treatment of neuropathic pain may he formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of neuralgia, severe pain, chronic pain, chemotherapy induced pain, neuropathic pain, post herpetic neuralgia, neuralgia, motor neurone disease, diabetic neuropathy, postherpetic neuralgia, injury, post-operative pain, osteoarthritis, rheumatoid arthritis, multiple sclerosis, spinal cord injury, migraine, HIV related neuropathic pain, cancer pain and lower back pain.
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors
Shen, Hong C.,Ding, Fa-Xiang,Deng, Qiaolin,Xu, Suoyu,Chen, Hsuan-shen,Tong, Xinchun,Tong, Vincent,Zhang, Xiaoping,Chen, Yuli,Zhou, Gaochao,Pai, Lee-Yuh,Alonso-Galicia, Magdalena,Zhang, Bei,Roy, Sophie,Tata, James R.,Berger, Joel P.,Colletti, Steven L.
supporting information; scheme or table, p. 5314 - 5320 (2010/07/03)
3,3-Disubstituted piperidine-derived trisubstituted urea entA-2b was discovered as a highly potent and selective soluble epoxide hydrolase (sEH) inhibitor. Despite the good compound oral exposure, excellent sEH inhibition in whole blood, and remarkable se
Synthesis of 2,4-substituted 3-oxo-1-phenylcyclopentane-1-carboxylic acids
Martirosyan,Gasparyan,Oganesyan,Arutyunyan,Martirosyan,Aleksanyan
, p. 1786 - 1788 (2007/10/03)
A procedure has been developed for the synthesis of 2,4-substituted 3-oxo-1-phenylcyclopentan-1-carboxylic acids, and substituent effects on particular steps of the synthesis have been studied.
SYNTHESIS AND PROPERTIES OF 1-ARYL-3-OXO-1-CYCLOPENTANECARBOXYLIC ACIDS AND THEIR DERIVATIVES
Mndzhoyan, Sh.L.,Martirosyan, A.O.,Ovakimyan, A.R.
, p. 1648 - 1651 (2007/10/02)
A synthesis was developed for 1-phenyl- and 1-(alkoxyphenyl)-3-oxo-1-cyclopentanecarboxylic acids, and some of their derivatives were obtained.
