22513-36-6Relevant articles and documents
Transition-metal-assisted radical/radical cross-coupling: A new strategy to the oxidative C(sp3)-H/N-H cross-coupling
Zhou, Liangliang,Tang, Shan,Qi, Xiaotian,Lin, Caitao,Liu, Kun,Liu, Chao,Lan, Yu,Lei, Aiwen
supporting information, p. 3404 - 3407 (2014/07/08)
A transition-metal-assisted oxidative C(sp3)-H/N-H cross-coupling reaction of N-alkoxyamides with aliphatic hydrocarbons is described. During the reaction, nitrogen radicals were generated from the oxidation of N-alkoxyamides. Experiments and DFT calculations revealed that transition-metal catalyst could lower the reactivity of the generated nitrogen radical by the coordination of the transition metal, which allowed the selective radical/radical cross-coupling with the transient sp3 carbon radical to construct C(sp3) - N bonds. Various C(sp3)-H bonds could be transformed into C(sp3)-N bonds through this radical amidation strategy.
A direct entry to substituted n-methoxyamines from n-methoxyamides via n-oxyiminium ions
Shirokane, Kenji,Kurosaki, Yusuke,Sato, Takaaki,Chida, Noritaka
supporting information; experimental part, p. 6369 - 6372 (2010/11/05)
Take the direct path: Sequential nucleophilic addition of N-methoxyamides using DIBAL and organometallic reagents provided substituted N-methoxyamines in one pot via five-membered chelated intermediates (see scheme, DIBAL=diisobutylaluminum hydride). The reaction allows functionalization of acyclic amides and macrolactams without a preactivation step, which is generally required for inert amide carbonyl groups. Copyright
Compounds with potential enzyme inhibitory acitivity. Hydroxylamine analogs of 2-propynylamine.
Moore,Cannon,McIsaac,Ho
, p. 45 - 48 (2007/10/06)
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