225779-17-9Relevant articles and documents
MODULATORS OF THE INTEGRATED STRESS RESPONSE PATHWAY
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Page/Page column 36; 38; 39, (2020/11/04)
The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1 to R3, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing one or more diseases or disorders associated with integrated stress response.
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity
Surivet, Jean-Philippe,Zumbrunn, Cornelia,Rueedi, Georg,Hubschwerlen, Christian,Bur, Daniel,Bruyère, Thierry,Locher, Hans,Ritz, Daniel,Keck, Wolfgang,Seiler, Peter,Kohl, Christopher,Gauvin, Jean-Christophe,Mirre, Azely,Kaegi, Verena,Dos Santos, Marina,Gaertner, Mika,Delers, Jonathan,Enderlin-Paput, Michel,Boehme, Maria
, p. 7396 - 7415 (2013/10/21)
There is an urgent need for new antibacterial drugs that are effective against infections caused by multidrug-resistant pathogens. Novel nonfluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) have the potential
A concise synthesis of (+)-α-allokainic acid via site- and diastereoselective intramolecular C-H insertion process
Anada, Masahiro,Sugimoto, Tomohiro,Watanabe, Nobuhide,Nakajima, Makoto,Hashimoto, Shun-Ichi
, p. 969 - 980 (2007/10/03)
A new route to (+)-α-allokainic acid commencing with L-serine has been established, wherein the key step involves a C3-C4 bond formation with a simultaneous creation of a C2, C3-trans and C3, C4-trans arrangement of substituents by Rh2(OAc)4-catalyzed C-H insertion reaction of α- diazoacetoacetamide tethered to (S)-4-(3-butenyl)-2,2-dimethyl-1,3- oxazolidine system. Taber's computational model confirms the observed diastereomer preference.