756464-00-3Relevant academic research and scientific papers
Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers
Hu, Lain-Yen,Ryder, Todd R.,Nikam, Sham S.,Millerman, Elizabeth,Szoke, Balazs G.,Rafferty, Michael F.
, p. 1121 - 1126 (2007/10/03)
Selective N-type Voltage Activated Calcium Channel (VACC) blockers have shown utility in several models of stroke and pain. In the process of searching for small molecules as N-type calcium channel blockers, we have identified a series of N,N-dialkylpeptidylamines (e.g., PD 175069) with potent functional activity at N-type VACC. Further modification of the leucine moiety of PD 175069 with a cyclized ring structure provides a series of novel molecules. Syntheses and pharmacological evaluation of the series are presented.
Synthesis of chiral nonracemic 4-trans-substituted pipecolic acid derivatives
Keenan, Terence P.,Yaeger, David,Holt, Dennis A.
, p. 4331 - 4341 (2007/10/03)
The syntheses and resolutions of enantiomerically enriched 4-phenyl, 4- tert-butyl, and 4-isopropyl pipecolic acids are described. Optically active diastereomers were prepared by diastereomeric salt formation with the chiral base, L-tyrosine hydrazide, to
