83282-36-4 Usage
Uses
Used in Pharmaceutical Industry:
4-Isopropylpicolinic acid is used as a synthetic intermediate for the preparation of selective N-type voltage-activated calcium channel (VACC) blockers. These blockers are important in the development of drugs that target specific ion channels, which play a crucial role in various physiological processes, including neurotransmission and muscle contraction. By selectively blocking N-type VACCs, these drugs can help in the treatment of various neurological disorders, such as chronic pain, epilepsy, and certain types of cancer.
In the synthetic preparation of selective N-type VACC blockers, 4-isopropylpicolinic acid serves as a key building block, providing the necessary structural features for the development of potent and selective compounds. The isopropyl group attached to the pyridine ring is believed to contribute to the selectivity and potency of the resulting VACC blockers, making 4-isopropylpicolinic acid a valuable component in the design and synthesis of these pharmaceutical agents.
Overall, 4-isopropylpicolinic acid is a versatile and important compound in the pharmaceutical industry, with its primary use being in the synthesis of selective N-type VACC blockers. Its unique structural features and potential applications make it a promising candidate for further research and development in the field of drug discovery and design.
Check Digit Verification of cas no
The CAS Registry Mumber 83282-36-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,2,8 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 83282-36:
(7*8)+(6*3)+(5*2)+(4*8)+(3*2)+(2*3)+(1*6)=134
134 % 10 = 4
So 83282-36-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO2/c1-6(2)7-3-4-10-8(5-7)9(11)12/h3-6H,1-2H3,(H,11,12)
83282-36-4Relevant academic research and scientific papers
LINCOMYCIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY
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Page 87-88, (2010/02/06)
Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.
Synthesis of chiral nonracemic 4-trans-substituted pipecolic acid derivatives
Keenan, Terence P.,Yaeger, David,Holt, Dennis A.
, p. 4331 - 4341 (2007/10/03)
The syntheses and resolutions of enantiomerically enriched 4-phenyl, 4- tert-butyl, and 4-isopropyl pipecolic acids are described. Optically active diastereomers were prepared by diastereomeric salt formation with the chiral base, L-tyrosine hydrazide, to
