2260-50-6

Usage

Uses

Used in Pharmaceutical Industry:
Acetylcholine Iodide is used as an acetylcholine receptor agonist for identifying, characterizing, and differentiating among types of cholinergic receptors. This application is essential in understanding the mechanisms of neurotransmission and developing targeted therapies for various neurological disorders.
Used in Research and Diagnostics:
Acetylcholine Iodide is used as a substrate to identify and characterize natural and mutated acetylcholinesterase(s). This application is vital in studying the function and regulation of acetylcholinesterase, an enzyme that breaks down acetylcholine in the synaptic cleft, and its role in various neurological conditions.
Used in Neurophysiology and Neuroscience:
Acetylcholine Iodide is employed in neurophysiological and neuroscience research to investigate the role of acetylcholine in cognitive functions, memory, and learning. This application helps in understanding the underlying mechanisms of these processes and contributes to the development of potential therapeutic interventions for cognitive disorders.
Used in Drug Development:
Acetylcholine Iodide is utilized in the development of drugs targeting the cholinergic system, which is involved in various physiological processes and diseases. By understanding the interactions between Acetylcholine Iodide and its receptors, researchers can design more effective drugs for treating conditions such as Alzheimer's disease, myasthenia gravis, and other neurological disorders.

Biochem/physiol Actions

Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

InChI:InChI=1/C7H16NO2.HI/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

Synthetic route

2',6'-dihydroxy-4'-methylacetophenone (1634-34-0) + choline iodide (17773-10-3) → acetylcholine iodide (2260-50-6)

Conditions	Yield
at 65℃; for 2h; Temperature;	93%

2-iodoethyl acetate (627-10-1) + trimethylamine (75-50-3) → acetylcholine iodide (2260-50-6)

Conditions	Yield
With diethyl ether

acetylcholine iodide (2260-50-6) → acetate (71-50-1)

Conditions	Yield
In solid for 5h; Ambient temperature; Irradiation;

acetylcholine iodide (2260-50-6) → choline iodide (17773-10-3)

Conditions	Yield
With tacrine monohydrochloride; acetylcholinesterase In water; sodium chloride at 25℃; Thermodynamic data; ΔF, other concentration of substrate, other inhibitor;
With acetylcholinesterase In aq. buffer at 20℃; for 0.416667h; pH=7.8; Enzymatic reaction;
With pillar[5]arene; acetylcholinesterase at 37℃; for 1.5h; Reagent/catalyst;
With 5,5'-dithiobis-(2-nitrobenzoic acid); acetylcholinesterase enzyme from electrophorus electricus (electric eel) In aq. phosphate buffer at 20℃; for 0.25h; pH=8;

acetylcholine iodide (2260-50-6) → acetic acid (64-19-7)

Conditions	Yield
With water; tetramethlyammonium chloride; acetylcholinoesterase at 38℃; Rate constant; other monoquaternary ammonium salts containing hydrophobic radicals as inhibitors of acetylcholinoesterase activity;

acetylcholine iodide (2260-50-6) + C39H39N9O6 (417698-69-2) → C39H39N9O6*C7H16NO2(1+)*I(1-)

Conditions	Yield
In chloroform-d1; d(4)-methanol Equilibrium constant;

acetylcholine iodide (2260-50-6) + silver picrate (146-84-9) → acetylcholine picrate (77822-10-7)

carboxylatopillar[5]arene sodium salt + acetylcholine iodide (2260-50-6) → C55H40O30(10-)*10Na(1+)*C7H16NO2(1+)*I(1-)

Conditions	Yield
In water-d2 at 21.84℃;

pillar[5]arene + acetylcholine iodide (2260-50-6) → 10H3N*C7H16NO2(1+)*I(1-)*C55H50O30

Conditions	Yield
In water at 29.99℃;

acetylcholine iodide (2260-50-6) → choline (62-49-7)

Conditions	Yield
With human serum butyrylcholinesterase In aq. buffer pH=5; Kinetics; Reagent/catalyst; Enzymatic reaction;

acetylcholine iodide (2260-50-6) + C107H100O17 → C107H100O17*C7H16NO2(1+)*I(1-)

Conditions	Yield
In chloroform-d1; [D3]acetonitrile at 29.84℃;

acetylcholine iodide (2260-50-6) + C107H100O17 → C107H100O17*C7H16NO2(1+)*I(1-)

Conditions	Yield
In chloroform-d1; [D3]acetonitrile at 29.84℃;

Upstream product

• 627-10-1 2-iodoethyl acetate 
• 75-50-3 trimethylamine 
• 1634-34-0 2',6'-dihydroxy-4'-methylacetophenone 
• 17773-10-3 choline iodide 

Downstream Products

• 77822-10-7 acetylcholine picrate 
• 62-49-7 choline 
• 17773-10-3 choline iodide 

Relevant academic research and scientific papers

Synthesis method of pharmaceutical synthesis intermediate acetylcholine iodide

The invention relates to a synthesis method of a pharmaceutical synthesis intermediate acetylcholine iodide. The method mainly includes the steps of: adding 3mol 3, 5-dhydroxyl-4-acetyl toluene and 4-5mol choline iodide into a reaction container, controlling the stirring speed at 110-130rpm, raising the temperature to 60-65DEG C, maintaining the temperature and performing stirring continuously until complete dissolution, conducting standing for 90-120min, lowering the solution temperature to 10-15DEG C, precipitating crystals, performing filtration, washing the crystals with a cyclohexane solution and a toluene solution, and conducting dehydration with a dehydrating agent, thus obtaining the finished product acetylcholine iodide.