226410-95-3

Basic information

• Product Name: 2,6-difluoro-4-(N-methylpivaloylamino)benzaldehyde
• CAS NO: 226410-95-3
• Molecular Weight: 255.264
• Mol File: 226410-95-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-difluoro-4-(N-methylpivaloylamino)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-difluoro-4-(N-methylpivaloylamino)benzaldehyde(226410-95-3)
• EPA Substance Registry System: 2,6-difluoro-4-(N-methylpivaloylamino)benzaldehyde(226410-95-3)

Safety Data

• Hazardous Substances Data: 226410-95-3(Hazardous Substances Data)

Upstream product

• 198077-69-9 N-(3,5-difluorophenyl)formamide 
• 470458-51-6 3,5-difluoro-N-methylbenzenamine 
• 129714-97-2 3,5-difluorobenzoyl chloride 
• 132980-99-5 3,5-difluorobenzamide 
• 372-39-4 3,5-difluoroaniline 
• 455-40-3 3,5-difluorobenzoic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 226410-94-2 3,5-difluoro-N-methyl-N-pivaloylaniline 

Relevant articles and documents

Prodrugs of neuron-selective monoamine oxidase inhibitors: Amino acid derivatives of 1-(4-aminophenyl)-2-aminopropanes

Six amino acid derivatives of 1-(4-aminophenyl)-2-aminopropanes and their parent amines were synthezised and tested for their potency and selectivity in inhibiting monoamine oxidase (MAO) in vitro and in vivo. The amino acid derivatives were 300-1000 times less potent than the parent amines in inhibiting the MAO-A activity in a rat brain mitochondrial preparation in vitro. All compounds, except the (R)-valinamide derivative (22), were potent inhibitors of MAO in the rat brain in vivo and were, like the parent amines markedly more potent within the monoaminergic neurons than in other neurons. The glycinamide derivative 7 showed the largest difference between intra- and extra-neuronal inhibition in serotonergic neurons. The time course of the inhibitory effect of 7 in vivo showed that it is a reversible inhibitor with a long duration.