198077-69-9

Basic information

• Product Name: Formamide, N-(3,5-difluorophenyl)- (9CI)
• Synonyms: Formamide, N-(3,5-difluorophenyl)- (9CI);N-(3,5-Difluoro-phenyl)-forMaMide
• CAS NO: 198077-69-9
• Molecular Formula: C₇H₅F₂NO
• Molecular Weight: 157.1175064
• Product Categories: HALIDE
• Mol File: 198077-69-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 83.8-84.6 °C
• Boiling Point: 271.9±30.0 °C(Predicted)
• Appearance: /
• Density: 1.370±0.06 g/cm3(Predicted)
• PKA: 13.43±0.70(Predicted)
• CAS DataBase Reference: Formamide, N-(3,5-difluorophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Formamide, N-(3,5-difluorophenyl)- (9CI)(198077-69-9)
• EPA Substance Registry System: Formamide, N-(3,5-difluorophenyl)- (9CI)(198077-69-9)

Safety Data

• Hazardous Substances Data: 198077-69-9(Hazardous Substances Data)

Usage

Uses

N-(3,5-difluorophenyl)formamide

Upstream product

• 64-18-6 formic acid 
• 372-39-4 3,5-difluoroaniline 
• 132980-99-5 3,5-difluorobenzamide 
• 455-40-3 3,5-difluorobenzoic acid 
• 129714-97-2 3,5-difluorobenzoyl chloride 
• 124-38-9 carbon dioxide 

Downstream Products

• 470458-51-6 3,5-difluoro-N-methylbenzenamine 
• 226410-98-6 N'-<1-(4-N-benzyl-N-methylamino-2,6-difluorophenyl)-2-propyl>-N,N-dibenzylglycinamide 
• 226411-11-6 Benzyl-[3,5-difluoro-4-((E)-2-nitro-propenyl)-phenyl]-methyl-amine 
• 226411-08-1 N-[3,5-difluoro-4-(2-nitro-propenyl)-phenyl]-2,2,N-trimethyl-propionamide 
• 226411-12-7 [4-(2-amino-propyl)-3,5-difluoro-phenyl]-benzyl-methyl-amine 
• 226410-97-5 4-(N-benzyl-N-methylamino)-2,6-difluorobenzaldehyde 
• 226410-95-3 2,6-difluoro-4-(N-methylpivaloylamino)benzaldehyde 
• 226410-94-2 3,5-difluoro-N-methyl-N-pivaloylaniline 

Relevant articles and documents

Tetracoordinate borates as catalysts for reductive formylation of amines with carbon dioxide

We report sodium trihydroxyaryl borates as the first robust tetracoordinate organoboron catalysts for reductive functionalization of CO2. These catalysts, easily synthesized from condensing boronic acids with metal hydroxides, activate main group element-hydrogen (E-H) bonds efficiently. In contrast to BX3 type boranes, boronic acids and metal-BAr4 salts, under transition metal-free conditions, sodium trihydroxyaryl borates exhibit high reactivity of reductive N-formylation toward a variety of amines (106 examples), including those with functional groups such as ester, olefin, hydroxyl, cyano, nitro, halogen, MeS-, ether groups, etc. The over-performance to catalyze formylation of challenging pyridyl amines affords a promising alternative method to the use of traditional formylation reagents. Mechanistic investigation supports electrostatic interactions as the key for Si/B-H activation, enabling alkali metal borates as versatile catalysts for hydroborylation, hydrosilylation, and reductive formylation/methylation of CO2.

Prodrugs of neuron-selective monoamine oxidase inhibitors: Amino acid derivatives of 1-(4-aminophenyl)-2-aminopropanes

Six amino acid derivatives of 1-(4-aminophenyl)-2-aminopropanes and their parent amines were synthezised and tested for their potency and selectivity in inhibiting monoamine oxidase (MAO) in vitro and in vivo. The amino acid derivatives were 300-1000 times less potent than the parent amines in inhibiting the MAO-A activity in a rat brain mitochondrial preparation in vitro. All compounds, except the (R)-valinamide derivative (22), were potent inhibitors of MAO in the rat brain in vivo and were, like the parent amines markedly more potent within the monoaminergic neurons than in other neurons. The glycinamide derivative 7 showed the largest difference between intra- and extra-neuronal inhibition in serotonergic neurons. The time course of the inhibitory effect of 7 in vivo showed that it is a reversible inhibitor with a long duration.