22682-29-7

Basic information

• Product Name: 2-METHYLBENZOPHENONE
• Synonyms: 2-PHENYL TOLYL KETONE;2-PHENYL CARBONYL TOLUENE;O-METHYLBENZOPHENONE
• CAS NO: 22682-29-7
• Molecular Formula: C₁₅H₁₄O
• Molecular Weight: 196.24
• Mol File: 22682-29-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: -18 °C
• Boiling Point: 125-127 °C0.3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.083 g/mL at 25 °C(lit.)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: n20/D 1.5958(lit.)
• CAS DataBase Reference: 2-METHYLBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLBENZOPHENONE(22682-29-7)
• EPA Substance Registry System: 2-METHYLBENZOPHENONE(22682-29-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 22682-29-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H14O/c1-11-6-5-8-13(10-11)15(16)14-9-4-3-7-12(14)2/h3-10H,1-2H3

Upstream product

• 932-31-0 ortho-tolylmagnesium bromide 
• 620-22-4 3-Methylbenzonitrile 
• 67-66-3 chloroform 
• 625-95-6 3-Iodotoluene 
• 16419-60-6 2-Methylphenylboronic acid 
• 7294-50-0 tri-o-tolylboroxine 
• 607-86-3 2-methylbenzoic anhydride 
• 95-46-5 2-methylphenyl bromide 
• 620-23-5 m-tolyl aldehyde 
• 118-90-1 ortho-methylbenzoic acid 
• 108-88-3 toluene 
• 933-88-0 ortho-toluoyl chloride 
• 49661-20-3 2-methyl-6-o-toluoyl-benzoic acid 
• 106-94-5 propyl bromide 

Downstream Products

• 137381-65-8 3-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester 
• 137382-63-9 3-(4-Oxo-3,4-dihydro-phthalazin-1-yl)-benzoic acid ethyl ester 
• 152567-99-2 3-(4-Oxo-3,4-dihydro-phthalazin-1-yl)-benzoic acid 
• 4091-00-3 C₁₅H₁₀O₅ 
• 90445-45-7 3-(m-tolyl)isobenzofuran-1(3H)-one 
• 84-54-8 2-methylanthracene-9,10-dione 
• 2159-37-7 carboxy-2 methyl-3' benzophenone 
• 90445-42-4 2-(3-methylbenzoyl)benzaldehyde 

Relevant articles and documents

Transition-metal-free carbonylation of aryl halides with arylboronic acids by utilizing stoichiometric CHCl3 as the carbon monoxide-precursor

Under transition-metal-free conditions, carbonylative Suzuki couplings of aryl halides with arylboronic acid using stoichiometric CHCl3 as the carbonyl source has been developed. The simple, efficient, and environmentally benign method was successfully applied to the synthesis of Fenofibric acid, naphthyl phenstatin, and carbon-13 labeled biaryl ketone.

Cobalt-Catalyzed Asymmetric Hydrogenation of 1,1-Diarylethenes

Highly enantioselective cobalt-catalyzed hydrogenation of 1,1-diarylethenes was developed by using bench-stable chiral oxazoline iminopyridine-cobalt complexes as precatalysts. A unique o-chloride effect was observed to achieve high enantioselectivity. Easy removal as well as further transformations of the chloro group make this protocol a potentially useful alternative to synthesize various chiral 1,1-diarylethanes. This process can be successfully performed under 1 atm of hydrogen at room temperature on gram scale.

Rhodium-catalyzed ortho acylation of aromatic carboxylic acids

New directions: The carboxylic acid functional group directs the ortho acylation of benzoic acids with carboxylic anhydrides in the presence of a rhodium catalyst (see scheme; cod=cyclo-1,5-octadiene). The acylation at the ortho position is complementary to the meta selectivity of Friedel-Crafts reactions. The resulting products can undergo protodecarboxylation to deliver an aryl ketone. Copyright