184968-72-7

Upstream product

• 184968-61-4 3-(3,4-di-chlorophenyl)-4-pentenoic acid 
• 315682-11-2 3-(3,4-dichloro-phenyl)-2-propene-1-ol acetate 
• 82475-75-0 methyl 3-(3,4-dichlorophenyl)-2-propenoate 
• 148775-22-8 3-(3,4-dichlorophenyl)-prop-2-en-1-ol 
• 7312-27-8 3,4-Dichlorocinnamic acid 
• 40807-61-2 4-hydroxy-4-phenylpiperidin 
• 226917-14-2 [[((3,5-bis(trifluoromethyl)phenyl)methoxy)-methyl]-2-(3,4-dichlorophenyl)]-4-hydroxy-4-phenyl-1-piperidinebutanol 
• 184968-66-9 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-tetrahydro-furan-2-ol 
• 315682-14-5 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one 
• 199997-50-7 4-(3,4-dichloro-phenyl)-5-hydroxymethyl-dihydro-furan-2-one 

Relevant academic research and scientific papers

SUBSTITUTED OXIMES AS NEUROKININ ANTAGONISTS

Compounds within the genus represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R is H, methyl, ethyl, -CH2CN, -CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, (a), (b), (c), (d) or (e); R is methyl or ethyl; and Z is substituted piperidinyl.

The design and synthesis of novel NK1/NK2 dual antagonists

Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class. The addition of the amino or the oxime functional group results in the reversal of the stereochemical preference of the NK2 receptor. (C) 2000 Elsevier Science Ltd.

SUBSTITUTED OXIMES, HYDRAZONES AND OLEFINS AS NEUROKININ ANTAGONISTS

Compound represented by the structural formula STR1 or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or3; b, d and e are independently 0, 1 or 2;R is H, C 1-6 alkyl,--OH or C 2-C 6 hydroxyalkyl;A is an optionally su