315682-11-2

Upstream product

• 1122-58-3 dmap 
• 148775-22-8 3-(3,4-dichlorophenyl)-prop-2-en-1-ol 
• 75-36-5 acetyl chloride 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 40950-94-5 ethyl (E)-3-(3,4-dichloro-phenyl)-2-propenoate 
• 108-24-7 acetic anhydride 
• 591-87-7 Allyl acetate 
• 95-50-1 1,2-dichloro-benzene 
• 82475-75-0 methyl 3-(3,4-dichlorophenyl)-2-propenoate 
• 7312-27-8 3,4-Dichlorocinnamic acid 

Downstream Products

• 184968-61-4 3-(3,4-di-chlorophenyl)-4-pentenoic acid 
• 226917-14-2 [[((3,5-bis(trifluoromethyl)phenyl)methoxy)-methyl]-2-(3,4-dichlorophenyl)]-4-hydroxy-4-phenyl-1-piperidinebutanol 
• 184968-72-7 1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone 
• 184968-66-9 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-tetrahydro-furan-2-ol 
• 315682-14-5 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one 
• 199997-50-7 4-(3,4-dichloro-phenyl)-5-hydroxymethyl-dihydro-furan-2-one 

Relevant academic research and scientific papers

Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity

In the presence of a neutral dppf-modified iridium catalyst and Cs2CO3, linear allylic acetates react with primary amines to form products of hydroamination with complete 1,3-regioselectivity. The collective data, including deuterium labeling studies, corroborate a catalytic mechanism involving rapid, reversible acetate-directed aminoiridation with inner-sphere/outer-sphere crossover followed by turnover-limiting proto-demetalation mediated by amine.

Access to cinnamyl derivatives from arenes and allyl esters by a biomimetic aerobic oxidative dehydrogenative coupling

An efficient biomimetic aerobic oxidative dehydrogenative alkenylation of arenes with allyl esters is presented. The reaction proceeds under an ambient pressure of oxygen with relatively low catalyst loading of palladium acetate, employing catalytic amounts of electron-transfer mediators (ETMs). This study represents a new environmentally friendly method for the synthesis of cinnamyl derivatives.

SUBSTITUTED ARYLALKYLAMINES AS NEUROKININ ANTAGONISTS

Aralkylamine derivatives of formula (I) and their salts are new: A1 = CH2R6, OR6, NR6R7, SOeR13, (CR6R7)qOR6, (CR6R7)qNR6R7 or (CR6R7)qSOeR13; q = 1-6; A2 = H; or A1+A2 = O, CR6R7, NOR6 or S; Q = R5-phenyl, R5-naphthyl, SR6, NR6R7, OR6 or R5-heteroaryl; T

The design and synthesis of novel NK1/NK2 dual antagonists

Functional probing of the backbone of the Sanofi NK2 antagonist SR 48968 has resulted in the discovery of two new classes of NK1/NK2 dual antagonists: the diamine class and the oxime class. The addition of the amino or the oxime functional group results in the reversal of the stereochemical preference of the NK2 receptor. (C) 2000 Elsevier Science Ltd.

SUBSTITUTED OXIMES, HYDRAZONES AND OLEFINS AS NEUROKININ ANTAGONISTS

Compound represented by the structural formula STR1 or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or3; b, d and e are independently 0, 1 or 2;R is H, C 1-6 alkyl,--OH or C 2-C 6 hydroxyalkyl;A is an optionally su