22706-12-3

Upstream product

• 6956-33-8 dibenzylidenethiocarbohydrazide 
• 22706-11-2 4-amino-3-phenyl-1H-1,2,4-triazole-5(4H)-thione 
• 100-52-7 benzaldehyde 
• 93-89-0 benzoic acid ethyl ester 
• 613-94-5 benzoic acid hydrazide 
• 38539-87-6 potassium 3-benzoyldithiocarbazinate 
• 22706-11-2 3-phenyl-4-amino-5-mercapto-1,2,4-triazole 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 1329020-31-6 3,6-diphenyl-7-ethoxycarbonyl-1H-pyrazolo[5,1-c][1,2,4]triazole 
• 1269527-26-5 6-{[4-(benzylideneamino)-5-phenyl-4H-1,2,4-triazol-3-ylthio]methyl}-N₂-o-tolyl-1,3,5-triazine-2,4-diamine 
• 1269527-25-4 6-{[4-(benzylideneamino)-5-phenyl-4H-1,2,4-triazol-3-ylthio]methyl}-N₂-(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine 

Relevant academic research and scientific papers

Synthesis, characterization, antimicrobial, and MOE evaluation of nano 1,2,4-triazole-based Schiff base ligand with some d-block metal ions

Three new metal complexes of 4-(benzylideneamino)-5-phenyl-4H-1,2,4-triazole-3-thiol ligand (L) and three transition metal ions: Fe (III), Cu (II), and Zn (II) were synthesized and characterized. The ligand derived from 4-amino-5-phenyl-1,2,4-triazole-3-thiol and benzaldehyde was synthesized in a 1:1 molar ratio. All the chelates were characterized by elemental analysis, conductivity measurements, thermal analysis, FT-IR, and 1H-NMR spectroscopy. The IR spectrum revealed that the Schiff base ligand coordinated in a neutral bidentate manner with the metal ions through the azomethine N and thiol S. The thiol group coordinated to the metal ions without proton displacement as confirmed from the 1H NMR spectra. The conductivity data showed the electrolytic nature of the Fe (III) and Cu (II) complexes while the Zn (II) complex was nonelectrolyte. All metal complexes had octahedral structure as depicted by spectral and elemental analyses. The complexes start decomposition at 35°C, and they decomposed in four to five steps. The scanning electron microscope (SEM) analysis confirmed the presence of metal complexes in nanostructure. The 1,2,4-triazole Schiff base ligand (L) and its transition metal complexes have been screened for their antibacterial (Gram [+] bacteria): Bacillis subtilis and Staphylococcus aureus, (Gram [?] bacteria): Escherichia coli and Pseudomonas aeruginosa and two fungi: Candida albicans and Aspergillus flavus by agar diffusion method. The two metal complexes were subjected to molecular docking study against crystal structure of Aspergillus fumigatus (PDB ID: 6NE0) and crystal structure of Mycobacterium tuberculosis (PDB ID: 5UHF). The mode of binding between the A. fumigatus (PDB ID: 6NE0) and Mycobacterium tuberculosis strains and the complexes was discussed.

Synthesis and Evaluation of Antioxidant, Antibacterial, and Target Protein-Molecular Docking of Novel 5-Phenyl-2,4-dihydro-3H-1,2,4-triazole Derivatives Hybridized with 1,2,3-Triazole via the Flexible SCH2-Bonding

Abstract: Synthesis of some new 5-phenyl-2,4-dihydro-3H-1,2,4-triazole derivatives as hybrids with 1,2,3-triazoles via a flexible bonding, and their antioxidant and antibacterial activity have been studied. IR, 1H and 13C NMR spectra

Impact of inclusion complex formation on antibacterial, antioxidant and anthelmintic activities of some 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols

Three different 4-arylidenamino-5-phenyl-4H-l,2,4-triazole-3-thiols have been synthesized and their inclusion complexes are prepared with β-cyclodextrin. The compounds and their inclusion complexes have been characterized by studying their physical and spectral properties. The determination of thermodynamic stability constant and standard free energy change indicates that inclusion complexes of the newly synthesized compounds are stable and their formation is thermodynamically allowed. Finally, the compounds and their inclusion complexes are screened for antibacterial, antioxidant and anthelmintic activities. It is found that inclusion complex formation increases the antibacterial, antioxidant and anthelmintic activities significantly as compared to naked compounds. The higher pharmacological activities have been explained in terms of enhanced solubility in the systemic circulation which makes them more available to specific tissues for better therapeutic efficacy.

Studies on Absorption and Emission Characteristics of Inclusion Complexes of Some 4-Arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols

The inclusion complexes of a series of 4-arylidenamino-5-phenyl-4H-1, 2, 4-triazole-3-thiols have been prepared with β-cyclodextrin. The compounds and their inclusion complexes have been characterized by studying their physical and spectral properties. Th

Antibacterial, antioxidant and anthelmintic studies of inclusion complexes of some 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols

A series of 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols have been synthesised and their inclusion complexes have been prepared with β-cyclodextrin. The compounds and their inclusion complexes have been characterised by studying their physical and

Efficient synthesis and antimicrobial activity of some novel S-β-d-glucosides of 5-aryl-1,2,4-triazole-3-thiones derivatives

A series of 3-S-β-d-glucosides-4-arylideneamino-5-aryl-1,2,4-triazoles were rationally designed and synthesized according to the principle of superposition of bioactive substructures by the combination of 1,2,4-triazole, Schiff base and glucosides. The structures of the target compounds have been characterized by 1H NMR, 13C NMR, IR, MS and HRMS. All the newly synthesized compounds have been evaluated for their antimicrobial activities in vitro against Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 8099) as well as Monilia albican (ATCC 10231). The bioactive assay showed that most of the tested compounds displayed variable inhibitory effects on the growth of the Gram-positive bacterial strain (Staphylococcus aureus), Gram-negative bacterial strains (Escherichia coli) and fungal strains (Monilia albican). All the target compounds exhibited better antifungal activity than antibacterial activity. Especially, compounds 6b, 6c, 6f, 6j, 6k and 6l showed excellent activity against fungus Monilia albican with MIC values of 16 μg/mL.

Synthesis and antiviral activity of benzimidazolyl-and triazolyl-1,3,5- triazines

A novel series of 1,3,5-triazine analogs was successfully synthesized through conjugation with benzimidazole or 1,2,4-triazole derivatives via a methylenethio linker. The new analogs were in vitro evaluated against HSV-1 in Vero cells; among these analogs, two compounds exhibited good effect in inhibiting HSV-1 replication (for compound 5p: EC50 = 3.5 μg/ml, SI = 358; for compound 5r: EC50 = 5.0 μg/ml, SI = 300) in comparison to acyclovir. Springer Science+Business Media, LLC 2011.

Stereoselective synthesis of dihydrothiadiazinoazines and dihydrothiadiazinoazoles and their pyrolytic desulfurization ring contraction

Intramolecular base catalyzed C-C bond formation led to exclusive stereoselective syntheses of trans-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazines, trans-7,8-dihydro-6H-[1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4- ones, and trans-3,4-dihydro-2H-

Anodic formation of 3,6-diaryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and 2(3-aryl-5-methyl-1H-[1,2,4]triazol-1-yl)-5-aryl-1,3,4-thiadiazoles

3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles together with the unknown systems 2-(3-aryl-5-methyl-1H-[1,2,4]triazol-1-yl)-5-aryl-1,3,4- thiadiazoles were obtained by anodic oxidation, under aprotic conditions, of aryl aldehyde N-(5-aryl-1,3,

Spectral and equilibrium studies on some new derivatives of 4-amino-5-phenyl-3-mercapto-1,2,4-triazole

4-Amino-5-phenyl-3-mercapto-1,2,4-triazole (APMT), 4-(4′-methoxy) benzylidineamino-5-phenyl-3-mercapto-1,2,4-triazole (PMBPMT), 4-benzylidineamino-5-phenyl-3-mcrcapto-1,2,4-triazole (BPMT), 4-(2′-hydroxy)benzylidineamino-5-phenyl-3-mercapto-1,2,4-triazole (HBPMT) and 4-amino-5-(4′-nitro)phenyl-3-mercapto-1,2,4-triazole (ANPMT) were synthesized and characterized by elemental analyses, IR, 1H NMR, 13C NMR, DEPT and Mass spectral studies. Proton dissociation constants of these compounds in 70% v/v dioxan water medium at 303 K. and 0.1 M (KNO3) ionic strength were measured. The order of the pKa corresponding to mercapto group follows the sequence : PMBPMT > BPMT > HBPMT > APMT > ANPMT.