227449-26-5

Upstream product

• 227449-09-4 ethyl 2-chloro-4-(3-methylanilino)pyrimidine-5-carboxylate 
• 108-44-1 1-amino-3-methylbenzene 
• 51940-64-8 ethyl 2,4-dichloropyrimidine-5-carboxylate 

Downstream Products

• 227449-48-1 2-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-4-(m-tolylamino)pyrimidin-5-carboxamide 
• 643087-03-0 2-chloro-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide 
• 227449-71-0 2-(2-aminoethylamino)-4-(3-methylanilino)pyrimidine-5-carboxamide 
• 643087-54-1 2-{[2-(4-hydroxyphenyl)ethyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxylic acid 

Relevant academic research and scientific papers

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives

Spleen tyrosine kinase (Syk) is a non-receptor-type tyrosine kinase which mediates diverse responses in haematopoietic cells. Therefore, Syk is an attractive therapeutic target, and in a study of Syk inhibitors as potentially new therapeutic agents, we di

DIAMINOPYRIMIDINECARBOXA MIDE DERIVATIVE

A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided. A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.