Proquazone

Base Information

• Chemical Name: Proquazone
• CAS No.: 22760-18-5
• Molecular Formula: C18H18 N2 O
• Molecular Weight: 278.354
• Hs Code.: 2933990090
• European Community (EC) Number: 245-203-7
• UNII: 42VPJ2980S
• DSSTox Substance ID: DTXSID4021210
• Nikkaji Number: J11.480D
• Wikipedia: Proquazone
• Wikidata: Q7250480
• NCI Thesaurus Code: C73093
• Metabolomics Workbench ID: 144598
• ChEMBL ID: CHEMBL268501
• Mol file: 22760-18-5.mol

Synonyms:1-isopropyl-4-phenyl-7-methyl-2-(1H)-quinazoline;Biarison;proquazone;RU 43-715

Chemical Property of Proquazone

Chemical Property:

• Vapor Pressure: 5.79E-08mmHg at 25°C
• Melting Point: 137-138°
• Refractive Index: 1.5700 (estimate)
• Boiling Point: 440.6°Cat760mmHg
• PKA: 0.74±0.20(Predicted)
• Flash Point: 220.3°C
• PSA: 34.89000
• Density: 1.12g/cm³
• LogP: 3.95280
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 278.141913202
• Heavy Atom Count: 21
• Complexity: 423

Purity/Quality:

98%Min ^*data from raw suppliers

Proquazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3
• Uses: Anti-inflammatory. Proquazone is a non-steroidal anti-inflammatory drug.

Technology Process of Proquazone

There total 6 articles about Proquazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-isopropyl-7-methyl-4-phenyl-5,6,7,8-tetrahydro-1H-quinazolin-2-one (40235-08-3) → proquazone (22760-18-5)

Guidance literature:

With hydrogen sulfide; In 5,5-dimethyl-1,3-cyclohexadiene;

Reference yield:

carbitol (2-[2-ethoxyethoxy]ethanol) + 1-isopropyl-7-methyl-4-phenyl-5,6,7,8-tetrahydro-1H-quinazolin-2-one (40235-08-3) → proquazone (22760-18-5)

Guidance literature:

With hydrogenchloride; sodium hydroxide; hydrogen sulfide; calcium chloride; In benzene;

Reference yield:

2-(N-isopropylamino)-4-methylbenzophenone (23070-81-7) → proquazone (22760-18-5)

Guidance literature:

With urea; benzoic acid; In toluene;

upstream raw materials:

phenylmagnesium bromide

1-isopropyl-7-methyl-4-phenyl-5,6,7,8-tetrahydro-1H-quinazolin-2-one

methyl carbamate

2-(N-isopropylamino)-4-methylbenzophenone

Refernces

Synthesis of novel 2-pyrazolyl-4(3H)-quinazolinones

10.1002/ardp.19903231004

The research focuses on the synthesis and antiinflammatory activity evaluation of four novel series of pyrazolyl-4(3H)quinazolinones. The compounds were prepared through reactions involving 3-aryl-2-hydrazino-4(3H)-quinazolinones and various derivatives of ethyl acetoacetate, acetylacetone, or diethyl malonate. Key chemicals used in the synthesis include 3-aryl-2-hydrazino-4(3H)-quinazolinones, ethyl antipyrylazoacetate, antipyrylazoacetylacetone, diethyl antipyrylhydrazonomalonate, and diazotized aminoantipyrine. The structures of the synthesized compounds were confirmed using IR, 'H-NMR, and elemental analyses. The antiinflammatory activity of representative compounds was assessed using the cotton pellet granuloma bioassay in rats, revealing that the tested compounds significantly inhibited granuloma formation, with some showing activity comparable to the reference standard Proquazone.

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