227783-07-5

Usage

Uses

Used in Pharmaceutical Industry:
(1R,3S)-1,3-Cyclohexanedicarboxylic acid, monomethyl ester is used as a raw material for the synthesis of various organic compounds and pharmaceuticals. Its unique structure and reactivity make it a valuable building block for creating bioactive molecules with potential therapeutic applications.
Used in Polymer and Resin Production:
In the chemical industry, (1R,3S)-1,3-Cyclohexanedicarboxylic acid, monomethyl ester is utilized in the production of polymers, resins, and coatings. Its chemical properties contribute to the formation of high-quality materials with specific characteristics, such as durability, flexibility, and resistance to environmental factors.
Used in Research and Development:
(1R,3S)-1,3-Cyclohexanedicarboxylic acid, monomethyl ester has potential applications in the field of medicinal chemistry, where it serves as a key component in the development of new drugs and therapeutic agents. Researchers leverage its versatile reactivity to explore novel chemical pathways and synthesize innovative bioactive compounds with potential health benefits.

InChI:InChI=1/C9H14O4/c1-13-9(12)7-4-2-3-6(5-7)8(10)11/h6-7H,2-5H2,1H3,(H,10,11)/t6-,7+/m0/s1

Upstream product

• 62638-06-6 dimethyl cyclohexane-1,3-dicarboxylate 
• 6998-82-9 dimethyl cis-1,3-cyclohexanedicarboxylate 
• 67-56-1 methanol 
• 4355-31-1 3-oxabicyclo[3.3.1]nonane-2,4-dione 
• 10021-92-8 dimethyl cyclohexane-trans-1,3-dicarboxylate 
• 4355-31-1 3-oxabicyclo<3.3.1>nonane-2,4-dione 
• 3971-31-1 cyclohexane-1,3-dicarboxylic acid 

Downstream Products

• 122699-77-8 tert-butyl 3-(methoxycarbonyl)cyclohexanecarboxylate 
• 201424-15-9 methyl 3-(hydroxymethyl)cyclohexane-1-carboxylate 
• 25090-40-8 3-Carbomethoxy-cyclohexan-1-carbonylchlorid 

Relevant academic research and scientific papers

HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo[l,5-a]pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo[l,5-a]pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8- substituted imidazo[l,5-a]pyridines that can be useful for inhibiting indoleamine 2,3- dioxygenase and/or tryptophane 2,3-dioxygenase and for treating diseases or disorders mediated thereby.

Highly enantioselective desymmetrizations of meso-anhydrides

Readily available, low molecular cyclohexane-based organocatalysts promote highly enantioselective desymmetrizations of cyclic meso-anhydrides applying alcohols and benzyl mercaptan as nucleophiles. Both succinic and glutaric anhydrides furnished the corresponding products with up to 96% ee in mostly quantitative yields.

Pyridine derivatives

Pyridine compounds of general formula: wherein —R1represents in which R11is hydrogen, C1-6alkyl, halogen, hydroxy, C1-12alkoxy, nitro, amino, C1-6alkylsulfonylamino, C1-6alkoxycarbonyl, C1-6alkylamino, di(C1-6alkyl)amino, C1-6alkanoylamino, phenyl C1-6alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2represents hydrogen or halogen; R3represents hydrogen, —CR31R32R33, or —NR34R35; R4is hydrogen, carbamoyl, CN, carboxyl, etc.; R5is amino, C1-6alkylamino, di C1-6alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.

Enzymatic desymmetrization of cis-1,3-cyclohexanedicarboxylic acid diesters

cis-1,3-Cyclohexanedicarboxylic acid (1,3-CHDA) monoesters were prepared in high overall yield and high enantiomeric purity using a three step process from cis/trans-1,3-CHDA. The asymmetry is induced by an enzymatic hydrolytic desymmetrization of a meso

Thiazolidinone compounds and composition for angina pectoris comprising the compounds as an active ingredient

A thiazolidinone compound represented by general formula (I) or a pharmacoligically acceptable salt thereof, STR1 wherein W represents sulfur or oxygen and X represents --N(R1)--, or alternatively X represents sulfur or oxygen and W represents --N(R1)--, and R1 represents hydrogen, alkyl or substituted alkyl; R2 and R3 are the same or different from each other, and each represents hydrogen, alkyl, substituted alkyl, aryl, or 5- or 6-membered heteroaryl; R4 represents hydrogen, alkyl or substituted C1 -C4 alkyl; R5 represents substituted cycloalkyl which may contain nitrogen, provided the substituents include --B--ONO2 (wherein B represents a single bond or alkylene) as the indispensable member and alkyl groups as optional members; and A represents a single bond or alkylene, has an excellent anti-anginal effect and thus is useful as an angina pectoris remedy or preventive.

Reaction Pathways of 3-(3'-Methylenecyclobutyl)propyl and 2-(3'-Methylenecyclobutyl)ethyl Radicals

Molecular mechanics (MM2) calculations were used to predict the efficacy and regiochemical outcome of radical cyclizations involving the title radicals and others with further substitution at C1 on the ring.The MM2 results were generally ratifi