227941-14-2Relevant academic research and scientific papers
Modulating the expression of chirality in a mechanically chiral rotaxane
Gell, Charles E.,McArdle-Ismaguilov, Timur A.,Evans, Nicholas H.
supporting information, p. 1576 - 1579 (2019/02/07)
The expression of mechanical chirality by a hydrogen bond templated rotaxane, as detected by 1H NMR spectroscopy, may be modulated by affecting the co-conformational behaviour of the rotaxane through varying solvent or by addition of acid and b
Photo/nickel synergistic catalysis method for monoarylation of diol
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Paragraph 0040-0043, (2018/09/13)
The invention discloses a photo/nickel synergistic catalysis method for monoarylation of a diol. The method directly uses a brominated aromatic hydrocarbon and a diol as raw materials, wherein the brominated aromatic hydrocarbon and the diol are simple and easy to obtain, and adopts a BODIPY organic photosensitizer and an inexpensive nickel source to synergistically catalyze cross-coupling of thediol and the brominated aromatic hydrocarbon without an additionally-added ligand to realize selective monoarylation of a diol compound, and a mono/dual arylation ratio is up to 18:1. The method disclosed by the invention has good tolerance of functional groups and is suitable for a plurality of diol compounds with different structures, such as o-diol, 1,3-diol, 1,4-diol and monodisperse polyethylene glycol; more importantly, the photosensitizer used in the method has a low using amount, the reaction temperature is close to room temperature, and the method is green, economical and highly-efficient; and the advantages make the method have higher scale synthetic value and can serve social and economic development.
Bispidine compounds useful in the treatment of cardiac arrythmias
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Page 23, (2010/02/09)
There is provided compounds of formula I, 1 wherein R1, R2, R3, R4, R5, R6, R7, R41, R42, R43 R44, R45, R46, A and B have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
