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8-(4-METHOXYPHENYL)-8-OXOOCTANOIC ACID is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

22811-92-3

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22811-92-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 22811-92-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,8,1 and 1 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22811-92:
(7*2)+(6*2)+(5*8)+(4*1)+(3*1)+(2*9)+(1*2)=93
93 % 10 = 3
So 22811-92-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H20O4/c1-19-13-10-8-12(9-11-13)14(16)6-4-2-3-5-7-15(17)18/h8-11H,2-7H2,1H3,(H,17,18)

22811-92-3Downstream Products

22811-92-3Relevant academic research and scientific papers

(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors

Vaisburg, Arkadii,Bernstein, Naomy,Frechette, Sylvie,Allan, Martin,Abou-Khalil, Elie,Leit, Silvana,Moradei, Oscar,Bouchain, Giliane,Wang, James,Woo, Soon Hyung,Fournel, Marielle,Yan, Pu T.,Trachy-Bourget, Marie-Claude,Kalita, Ann,Beaulieu, Carole,Li, Zuomei,MacLeod, A. Robert,Besterman, Jeffrey M.,Delorme, Daniel

, p. 283 - 287 (2007/10/03)

A variety of ω-substituted alkanoic acid (2-amino-phenyl)-amides were designed and synthesized. These compounds were shown to inhibit recombinant human histone deacetylases (HDACs) with IC50 values in the low micromolar range and induce hyperacetylation of histones in whole cells. They induced expression of p21WAF1/Cip1 and caused cell-cycle arrest in human cancer cells. Compounds in this class showed efficacy in human tumor xenograft models.

Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors

Woo, Soon Hyung,Frechette, Sylvie,Khalil, Elie Abou,Bouchain, Giliane,Vaisburg, Arkadii,Bernstein, Naomy,Moradei, Oscar,Leit, Silvana,Allan, Martin,Fournel, Marielle,Trachy-Bourget, Marie-Claude,Li, Zuomei,Besterman, Jeffrey M.,Delorme, Daniel

, p. 2877 - 2885 (2007/10/03)

A series of new, structurally simple trichostatin A (TSA)-like straight chain hydroxamates were prepared and evaluated for their ability to inhibit partially purified human histone deacetylase 1 (HDAC-1). Some of these compounds such as 8m, 8n, 12, and 15

Inhibitors of histone deacetylase

-

, (2008/06/13)

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 3. ω (6,11 Dihydro 11 oxodibenz[b,e]oxepin 2 yl)alkanoic acids

Aultz,McFadden,Lassman

, p. 1499 - 1501 (2007/10/13)

ω-(6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-yl)butyric,-hexanoic, and -octanoic acids were evaluated in the carrageenan paw edema assay. The most active compound, the butyric acid analogue, was 1.80 times more potent than the hexanoic compound, 1.15 times m

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