22811-92-3

Basic information

• Product Name: 8-(4-METHOXYPHENYL)-8-OXOOCTANOIC ACID
• Synonyms: 8-(4-METHOXYPHENYL)-8-OXOOCTANOIC ACID
• CAS NO: 22811-92-3
• Molecular Formula: C₁₅H₂₀O₄
• Molecular Weight: 264.32
• Mol File: 22811-92-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 454°C at 760 mmHg
• Flash Point: 167.3°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 4.93E-09mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 8-(4-METHOXYPHENYL)-8-OXOOCTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-METHOXYPHENYL)-8-OXOOCTANOIC ACID(22811-92-3)
• EPA Substance Registry System: 8-(4-METHOXYPHENYL)-8-OXOOCTANOIC ACID(22811-92-3)

Safety Data

• Hazardous Substances Data: 22811-92-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H20O4/c1-19-13-10-8-12(9-11-13)14(16)6-4-2-3-5-7-15(17)18/h8-11H,2-7H2,1H3,(H,17,18)

Upstream product

• 505-48-6 octane-1,8-dioic acid 
• 10027-07-3 suberoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 855898-67-8 7-methoxycarbonylamino-heptanoic acid methyl ester 
• 29823-18-5 ethyl 7-bromoheptanoate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 51100-70-0 ethyl 7-iodoheptanoate 
• 362669-41-8 ethyl 7-(p-anisoyl)heptanoate 
• 22811-89-8 6-(p-Hydroxy-benzoyl)heptansaeure 
• 77-78-1 dimethyl sulfate 
• 100-66-3 methoxybenzene 
• 93164-08-0 methyl 8-(4-methoxyphenyl)-8-oxooctanoate 

Relevant articles and documents

(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors

A variety of ω-substituted alkanoic acid (2-amino-phenyl)-amides were designed and synthesized. These compounds were shown to inhibit recombinant human histone deacetylases (HDACs) with IC50 values in the low micromolar range and induce hyperacetylation of histones in whole cells. They induced expression of p21WAF1/Cip1 and caused cell-cycle arrest in human cancer cells. Compounds in this class showed efficacy in human tumor xenograft models.

Inhibitors of histone deacetylase

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.