22819-91-6

Usage

Uses

Used in Pharmaceutical Industry:
7-Chloroheptanenitrile is used as an intermediate in the synthesis of pharmaceuticals for its ability to be chemically modified and incorporated into various drug molecules.
Used in Pesticide Production:
7-Chloroheptanitrile is used in the production of pesticides, contributing to the development of effective and targeted pest control agents.
Used in Surfactant Manufacturing:
This chemical is used in the manufacturing of surfactants, which are essential in various industries for their properties to reduce surface tension and stabilize mixtures.
Used in Specialty Chemicals Production:
7-Chloroheptanitrile is also utilized in the production of specialty chemicals, where its unique properties can be leveraged for specific applications in different industries.

InChI:InChI=1/C7H12ClN/c8-6-4-2-1-3-5-7-9/h1-6H2

Upstream product

• 60274-60-4 1-chloro-5-iodopentane 
• 75-05-8 acetonitrile 
• 143-33-9 sodium cyanide 
• 2163-00-0 1,6-dichlorohexane 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 74-85-1 ethene 
• 506-77-4 cyanogen chloride 
• 629-08-3 heptanenitrile 
• 502-44-3 hexahydro-2H-oxepin-2-one 
• 78132-75-9 6-benzyloxy-hexanoic acid methyl ester 
• 126519-80-0 6-benzyloxyhexyl 4-methylbenzenesulfonate 
• 147566-01-6 7-(benzyloxy)heptanenitrile 
• 4547-43-7 methyl 6-hydroxycaproate 

Downstream Products

• 33695-75-9 7-(2,4-dichloro-phenoxy)-heptanenitrile 
• 23181-80-8 7-aminoheptanenitrile 
• 6066-95-1 7-Diaethylamino-heptannitril 
• 55096-96-3 7-Dibenzylamino-heptanenitrile 
• 76852-66-9 4',7-dichloroheptanophenone 
• 39520-64-4 7-phenylheptanenitrile 
• 112176-23-5 6-Phenyl-heptanenitrile 
• 18300-91-9 pentadecanenitrile 
• 76852-46-5 1-(4-Chloro-phenyl)-7-dimethylamino-heptan-1-one O-(2-methylamino-ethyl)-oxime 
• 76852-52-3 1-(4-Chloro-phenyl)-7-dimethylamino-heptan-1-one O-(2-amino-1-methyl-ethyl)-oxime 
• 76852-53-4 1-(4-Chloro-phenyl)-7-dimethylamino-heptan-1-one O-(2-amino-propyl)-oxime 
• 76852-47-6 1-(4-Chloro-phenyl)-7-dimethylamino-heptan-1-one O-(2-dimethylamino-ethyl)-oxime 
• 76852-48-7 1-(4-Chloro-phenyl)-7-dimethylamino-heptan-1-one O-(2-morpholin-4-yl-ethyl)-oxime 
• 76852-62-5 1-(4-Chloro-phenyl)-7-dimethylamino-heptan-1-one O-(2-thiomorpholin-4-yl-ethyl)-oxime 

Relevant academic research and scientific papers

Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists

Compound 1 (IC50 = 35.2 ± 7.2 μM), a moderate FXR antagonist was discovered via high-throughput screening. Structure-activity relationship studies indicated that the shape and the lipophilicity of the substituents of the aromatic ring affect the activity dramatically, increasing the shape and the lipophilicity of the substituents of the aromatic ring enhances the potency of FXR antagonists. Especially, when the OH at C2 position of the aromatic ring was replaced by the OBn substituent (analog 2b), its activity could be improved to IC50 = 1.1 ± 0.1 μM. Besides, the length of the linker and the tetrazole structure are essential for retaining the activity.

MECHANISMS OF FREE-RADICAL REACTIONS. XXIV. QUANTITATIVE DESCRIPTION OF THE POLAR EFFECTS OF SUBSTITUENTS ON THE KINETICS OF THE FREE-RADICAL CHLORINATION OF ALIPHATIC COMPOUNDS BY N-CHLOROPIPERIDINE

The free-radical chlorination of 1-substituted alkanes with electron-withdrawing substituents by N-chloropiperidine in trifluoroacetic acid was studied by the method of competing reactions, and the relative rate constants were obtained for all positions of the substrates.The data on the position selectivity can be described satisfactorily by means of an electrostatic model of the polar effect of the substituent, calculated according to the Kirkwood-Westheimer equation.The obtained characteristics of the electrostatic effect can be successfully applied to calculation of the substrate selectivity and the intermolecular relative rate constants for all the positions, beginning with the third.The Taft equation is unsuitable for description of the effect of substituents on the reaction rate.