228411-90-3Relevant academic research and scientific papers
The total synthesis of 20-hydroxyhepoxilins A3, new metabolites of the hepoxilin family of eicosanoids
Demin,Kochev,Manukina,Pace-Asciak,Pivnitsky
, p. 692 - 699 (2007/10/03)
An enantiodirected total synthesis of 20-hydroxyhepoxilins A3, new eicosanoids of the lipoxygenase metabolism of arachidonic acid, was perfomed. The synthetic samples were found to be identical to the major metabolite formed upon incubation of (85)-hepoxilin A3 with human neutrophiles, which demonstrated that it has the structure of (8S)-20-hydroxy-HxA3.
