22847-06-9Relevant articles and documents
MODIFIED AMINE LIPIDS
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Page/Page column 232, (2020/07/04)
The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
A simple oxidation of γ- and δ-lactones to oxocarboxylic acids by buffered sodium hypochlorite
D'Ambrosio, Michele,Guerriero, Antonio
, p. 631 - 633 (2007/10/03)
An efficient synthetic procedure is described for the preparation of 4- and 5-oxocarboxylic acids by reaction of the corresponding lactones with commercial bleach.
Chemoselective conversion of conjugated nitroalkenes into ketones by sodium borohydride-hydrogen peroxide: A new synthesis of 4-oxoalkanoic acids, dihydrojasmone and (±)exo-brevicomin
Ballini,Bosica
, p. 723 - 726 (2007/10/02)
A new, simple, cheap, and practical procedure for the direct transformation of α,β-unsaturated nitroalkenes into ketones has been realized by the NaBH4/H2O2 system. By this method, other functional groups such as C-C double bonds, ketals or aromatic nitro groups were preserved. Application of this methodology to the preparation of 4-oxoalkanoic acids, dihydrojasmone, and (±)-exobrevicomin is also reported.
An Efficient Approach to β-Oxoadipate Derivatives and γ-Oxo Acids by the Reformatsky Reaction of Ethyl α-Bromoalkanoates with Succinic Anhydride
Schick, Hans,Ludwig, Ralf
, p. 369 - 370 (2007/10/02)
Ethyl 2-bromoalkanoates react with zinc and succinic anhydride in dimethylformamide forming 2-substituted 1-ethyl hydrogen 3-oxoadipates (hexanedioates) isolable in a yield of 56 - 78percent.When subjected to decarboxylative saponification, they afford 4-oxoalkanoic acids in overall yields of 50 - 72percent
Process for preparation of 4- and 5-ketocarboxylic acids
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, (2008/06/13)
This invention is a novel synthesis of 4-and 5-ketocarboxylic acids which includes the reaction of the appropriate delta- or gamma-lactone with a chromosulfuric acid solution and separating the 4- or 5-ketocarboxylic acid product from the reduced solution.
SOME (E)-1,4-ALKADIENE DERIVATIVES AND THE SYNTHESIS OF 5-(3E,6-HEPTADIENYL)DIHYDRO-2(3H)-FURANONE
Voaden, Denys J.
, p. 53 - 64 (2007/10/02)
From 2-allyl-3-chlorotetrahydropyran, (E)-4,7-octadien-1-ol and (E)-4,7-octadienal were obtained.The aldehyde was conjugated with ethyl acrylate to give a γ-keto ester from which 5-(3E,6-heptadienyl)dihydro-2(3H)-furanone was prepared. 4-Oxo- and 4-hydroxy-derivatives of decanoic and undecanoic acids are discussed.
