22911-21-3

Usage

Type of compound

Organic chemical compound

Structure

a. Benzene derivative
b. Chlorine atom at the first carbon position
c. Three methoxy (CH3O) groups attached to the fourth carbon position

Functional groups

Chloromethyl ether

Applications

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Intermediate in the synthesis of other organic compounds
d. Production of dyes
e. Production of pigments
f. Production of perfumes

Potential uses

Development of novel materials and chemical processes

Chemical reactivity

Unique chemical structure and reactivity

Safety precautions

Toxic and can cause irritation upon contact with skin or eyes

Upstream product

• 67-56-1 methanol 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 115-10-6 Dimethyl ether 
• 10359-09-8 2-(4-chlorophenyl)-1,3-dithiane 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 1517-46-0 4-chloro-N-methyl-N-phenyl-benzamide 
• 333-27-7 methyl trifluoromethanesulfonate 
• 106-43-4 para-chlorotoluene 
• 5990-17-0 methyl 4-chlorobenzenecarbodithioate 
• 1067-55-6 dibutyldimethoxytin 

Downstream Products

• 91362-54-8 3-(4-chlorophenyl)-2,4,10-trioxaadamantane 
• 131505-65-2 1-(4-Chlorophenyl)-4-(4-fluorophenyl)-2,6,7-trioxabicyclo[2.2.2]octane 
• 1379506-00-9 C₂₅H₂₈ClNO₂SSi 
• 137256-69-0 C₇H₉ClN₄*2ClH 

Relevant academic research and scientific papers

Synthesis method of crude carboxylic ester (by machine translation)

The method is characterized in that the carboxylic ester and the ether are prepared by reacting a carboxylic ester with an ether at a certain temperature under the catalysis of a catalyst at a certain pressure for a certain time. (by machine translation)

Anodic oxidation of dithiane carboxylic acids: A rapid and mild way to access functionalized orthoesters

A new electrochemical methodology has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials.

Enantioselective Desymmetrization of cis-3,5- O-Arylidenecyclohexanones Catalyzed by Cinchona-Derived Quaternary Ammonium Salts

An enantioselective protocol for the desymmetrization of cis-3,5-O-arylidenecyclohexanones has been developed that proceeded under the catalysis of readily available and inexpensive Cinchona-derived quaternary ammonium salts. The synthetic relevance of the methodology was exemplified by the synthesis of a key intermediate that could be used in the preparation of the active pharmaceutical ingredient, paricalcitol (Zemplar).

INDIRECT ELECTROCHEMICAL SIDE-CHAIN OXIDATION OF ALKYL AROMATIC COMPOUNDS - SELECTIVE SYNTHESIS OF METHYL BENZOATES OR ORTHOBENZOIC ACID TRIMETHYLESTERS

The technically important side-chain oxidation of alkyl aromatic compounds to form either methyl benzoates or orthobenzoic acid trimethylesters can be performed electrochemically at low potentials in methanol solution using an undivided cell and tris(2,4-dibromophenyl)amine as redox catalyst.Under neutral or slightly acidic conditions methyl benzoates are selectively formed while under basic conditions the orthoesters are predominating.In a similar way ortho benzoic acid trimethylesters are formed selectively starting from benzaldehyde dimethylacetals.The redox catalyst is stable under the reaction conditions so that several thousand cycles can be performed without noticeable loss.