22911-21-3

Basic information

• Product Name: 1-chloro-4-(trimethoxymethyl)benzene
• Synonyms: 1-Chloro-4-(trimethoxymethyl)benzene; benzene, 1-chloro-4-(trimethoxymethyl)-
• CAS NO: 22911-21-3
• Molecular Formula: C₁₀H₁₃ClO₃
• Molecular Weight: 216.6614
• Mol File: 22911-21-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 228.9°C at 760 mmHg
• Flash Point: 73.1°C
• Density: 1.157g/cm³
• Vapor Pressure: 0.108mmHg at 25°C
• Refractive Index: 1.497
• CAS DataBase Reference: 1-chloro-4-(trimethoxymethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-4-(trimethoxymethyl)benzene(22911-21-3)
• EPA Substance Registry System: 1-chloro-4-(trimethoxymethyl)benzene(22911-21-3)

Safety Data

• Hazardous Substances Data: 22911-21-3(Hazardous Substances Data)

Usage

Type of compound

Organic chemical compound

Structure

a. Benzene derivative
b. Chlorine atom at the first carbon position
c. Three methoxy (CH3O) groups attached to the fourth carbon position

Functional groups

Chloromethyl ether

Applications

a. Intermediate in the synthesis of pharmaceuticals
b. Intermediate in the synthesis of agrochemicals
c. Intermediate in the synthesis of other organic compounds
d. Production of dyes
e. Production of pigments
f. Production of perfumes

Potential uses

Development of novel materials and chemical processes

Chemical reactivity

Unique chemical structure and reactivity

Safety precautions

Toxic and can cause irritation upon contact with skin or eyes

Upstream product

• 1126-46-1 Methyl 4-chlorobenzoate 
• 115-10-6 Dimethyl ether 
• 10359-09-8 2-(4-chlorophenyl)-1,3-dithiane 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 67-56-1 methanol 
• 1517-46-0 4-chloro-N-methyl-N-phenyl-benzamide 
• 333-27-7 methyl trifluoromethanesulfonate 
• 106-43-4 para-chlorotoluene 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 5990-17-0 methyl 4-chlorobenzenecarbodithioate 
• 1067-55-6 dibutyldimethoxytin 

Downstream Products

• 1379506-00-9 C₂₅H₂₈ClNO₂SSi 
• 131505-65-2 1-(4-Chlorophenyl)-4-(4-fluorophenyl)-2,6,7-trioxabicyclo[2.2.2]octane 
• 137256-69-0 C₇H₉ClN₄*2ClH 
• 91362-54-8 3-(4-chlorophenyl)-2,4,10-trioxaadamantane 

Relevant articles and documents

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Anodic oxidation of dithiane carboxylic acids: A rapid and mild way to access functionalized orthoesters

A new electrochemical methodology has been developed for the preparation of a wide variety of functionalized orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalized orthoesters from simple and readily available starting materials.

INDIRECT ELECTROCHEMICAL SIDE-CHAIN OXIDATION OF ALKYL AROMATIC COMPOUNDS - SELECTIVE SYNTHESIS OF METHYL BENZOATES OR ORTHOBENZOIC ACID TRIMETHYLESTERS

The technically important side-chain oxidation of alkyl aromatic compounds to form either methyl benzoates or orthobenzoic acid trimethylesters can be performed electrochemically at low potentials in methanol solution using an undivided cell and tris(2,4-dibromophenyl)amine as redox catalyst.Under neutral or slightly acidic conditions methyl benzoates are selectively formed while under basic conditions the orthoesters are predominating.In a similar way ortho benzoic acid trimethylesters are formed selectively starting from benzaldehyde dimethylacetals.The redox catalyst is stable under the reaction conditions so that several thousand cycles can be performed without noticeable loss.