229153-25-7

Upstream product

• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 102429-07-2 2-bromo-2',4'-difluoroacetophenone 
• 229153-21-3 2',4'-difluoro-α-(ethylthio)acetophenone 

Downstream Products

• 229153-29-1 2-[difluoro(ethylthio)methyl]-2-(2,4-difluorophenyl)oxirane 
• 229153-04-2 2-(2,4-difluorophenyl)-1-(ethylthio)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-2-propanol 
• 229153-08-6 1-[2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoro-2-methoxypropyl]-1H-1,2,4-triazole 
• 229153-10-0 (-)-2-(2,4-difluorophenyl)-1-(ethylsulfonyl)-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)-2-propanol 
• 229153-09-7 1-[2-(benzyloxy)-2-(2,4-difluorophenyl)-3-(ethylthio)-3,3-difluoropropyl]-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Novel fluorination reagent: IF5/Et3N-3HF

IF5 in Et3N-3HF was found to be a stable, non-hazardous, easy to handle, and inexpensive reagent that enables effective and selective fluorination of organic compounds under mild conditions.

Fluorination of sulfides using IF5-Et3N-3HF

Mono- and difluorinations of sulfides were achieved using a novel fluorinating reagent, IF5-Et3N-3HF. The reagent is applicable for substrates having various electron-withdrawing groups, such as an ester, amide, ketone, ni

Preparation process of difluoroacetophenone derivative

The invention relates to a process for preparing a difluoroacetophenone derivative (4) by alkylthionating a compound (1) into a compound (2) and reacting this compound with a compound (3). wherein X1is Cl, Br or I, X2and X3/sup

New antifungal 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety

New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via α,α-difluoro-α-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus

α, α-gem-difluorination of α-(alkylthio)acetophenone derivatives with N-Fluoropyridinium salts

The α, α-gem-difluorination of 2',4'-difluoro- α(methylthio)acetophenone (1a) with N-fluoropyridinium salts gave 2',4',α-tetrafluoro-α-(methylthio)acetophenone (3a). This reaction was accelerated by the addition of zinc chloride, zinc bromide or anhydrous iron(III) chloride, and higher yields than the reaction without additives were obtained. The gem- difluorination reaction using FP-T300 in the presence of zinc bromide was applicable to other α-(alkylthio)acetophenone derivatives (1).