555155-04-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(quinolin-5-yl)acetonitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its chemical structure provides a foundation for the development of new drug molecules, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-(quinolin-5-yl)acetonitrile serves as an essential component in the creation of agrochemicals. Its role in this industry is crucial for the synthesis of compounds that aid in crop protection and enhancement of agricultural productivity.
Used in Organic Synthesis:
2-(quinolin-5-yl)acetonitrile is utilized as a versatile building block in organic synthesis. Its unique structure allows for the formation of a wide range of organic compounds, expanding the possibilities for chemical research and innovation.
Used in Biological Research:
Due to its potential biological activities, 2-(quinolin-5-yl)acetonitrile is used in biological research to study its pharmacological properties. This research can lead to a better understanding of its interactions with biological systems and may contribute to the discovery of new therapeutic agents.

Upstream product

• 22934-41-4 quinoline-5-carbaldehyde 
• 2942-58-7 diethyl cyanophosphonate 
• 16178-42-0 quinolin-5-ylmethanol 
• 773837-37-9 sodium cyanide 
• 110333-07-8 5-(chloromethyl)quinoline 

Relevant academic research and scientific papers

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

N-Myristoyltransferase (NMT) represents an attractive drug target in parasitic infections such as malaria due to its genetic essentiality and amenability to inhibition by drug-like small molecules. Scaffold simplification from previously reported inhibitors containing bicyclic cores identified phenyl derivative 3, providing a versatile platform to study the effects of substitution on the scaffold, which yielded pyridyl 19. This molecule exhibited improved enzyme and cellular potency, and reduced lipophilicity compared to inhibitor 3. Further structure-based inhibitor design led to the discovery of 30, the most potent inhibitor in this series, which showed single-digit nM enzyme affinity and sub-μM anti-plasmodial activity.

Cyanoamidine P2X7 antagonists for the treatment of pain

Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles

Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonstrated.