230962-37-5Relevant academic research and scientific papers
Asymmetric synthesis of an MMP-3 inhibitor incorporating a 2-alkyl succinate motif
Ashcroft, Christopher P.,Challenger, Stephen,Derrick, Andrew M.,Storey, Richard,Thomson, Nicholas M.
, p. 362 - 368 (2013/09/06)
An efficient and practical synthesis is presented of the pharmaceutically active MMP-3 inhibitor UK-370,106 (1) via an olefination/catalytic asymmetric hydrogenation sequence. Commercially available 5-bromo-2-iodotoluene was converted in two steps to the
A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers
Fray, M. Jonathan,Dickinson, Roger P.,Huggins, John P.,Occleston, Nicholas L.
, p. 3514 - 3525 (2007/10/03)
The pathology of chronic dermal ulcers is characterized by excessive proteolytic activity which degrades extracellular matrix (required for cell migration) and growth factors and their receptors. The overexpression of MMP-3 (stromelysin-1) and MMP-13 (col
Matrix metalloprotease inhibitors
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, (2012/04/23)
Compounds of formula (I): or pharmaceutically acceptable salts thereof, or solvates of either entity, wherein the substituents have the values described herein, are useful as matrix metalloprotease (MMP) inhibitors
Novel olefination process to itaconate and succinate derivatives
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, (2008/06/13)
An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives.
