2311-21-9

Basic information

• Product Name: FOR-PHE-OME
• Synonyms: FORMYL-L-PHENYLALANINE METHYL ESTER;FOR-PHENYLALANINE-OME;FOR-PHE-OME
• CAS NO: 2311-21-9
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Mol File: 2311-21-9.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: FOR-PHE-OME(CAS DataBase Reference)
• NIST Chemistry Reference: FOR-PHE-OME(2311-21-9)
• EPA Substance Registry System: FOR-PHE-OME(2311-21-9)

Safety Data

• Hazardous Substances Data: 2311-21-9(Hazardous Substances Data)

Usage

General Description

FOR-PHE-OME, also known as 4-Fluoroamphetamine, is a psychoactive drug and empathogen-entactogen belonging to the substituted amphetamine class. It is a serotonergic and dopaminergic neurotoxin that inhibits the reuptake of serotonin, norepinephrine, and dopamine in the brain, leading to increased levels of these neurotransmitters in the synaptic cleft. FOR-PHE-OME is known for its entactogenic effects, including feelings of empathy, closeness, and emotional openness, as well as stimulant effects such as increased energy, alertness, and euphoria. Due to its potential for neurotoxicity and abuse, FOR-PHE-OME is classified as a controlled substance in many countries and is illegal to manufacture, possess, or distribute for non-medical purposes.

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 77287-34-4 formamide 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 16712-16-6 ammonium formate 
• 68-12-2 N,N-dimethyl-formamide 
• 109-94-4 formic acid ethyl ester 
• 67-56-1 methanol 
• 13200-85-6 N-formyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 150760-95-5 formic acid cyanomethyl ester 
• 19427-28-2 N-formyl-L-aspartic acid 
• 2258-42-6 formyl acetic anhydride 
• 88420-63-7 (S)-3-Phenyl-2-(2,2,2-trichloro-1-hydroxy-ethylamino)-propionic acid methyl ester 
• 64-18-6 formic acid 

Downstream Products

• 84773-29-5 (S)-(+)-2-(N-methylamino)-3-phenylpropanol 
• 43041-59-4 methyl (S)-(-)-2-isocyano-3-phenylpropionate 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 1258863-43-2 (S)-methyl 2-isoselenocyanato-3-phenylpropanoate 
• 1258863-66-9 (S)-methyl 2-(3-cyclohexylselenoureido)-3-phenylpropanoate 
• 1258863-67-0 C₁₇H₁₈N₂O₂Se 
• 1258863-70-5 C₁₉H₂₂N₂O₂Se 
• 67591-34-8 C₁₆H₁₄N₂OSe 
• 1258863-76-1 C₁₆H₂₀N₂OSe 
• 1258863-71-6 C₁₉H₂₂N₂O₂Se 
• 95713-60-3 L-Phe-L-FDAA 
• 95713-61-4 L-FDAA-D-Phe 
• 1346413-92-0 C₃₂H₄₃N₃O₆ 
• 2439-60-3 N-methyl-L-phenylalanine methyl ester 

Relevant articles and documents

A simple and convenient synthesis of N-formyl amino acid esters under mild conditions

A variety of amino acid ester hydrochlorides react with cyanomethyl formate at room temperature to give the N-formyl amino acid esters in good yields and without racemization.

Capsicum annuum fruit extract: A novel reducing agent for the green synthesis of zno nanoparticles and their multifunctional applications

A simple, efficient and convenient method for the preparation of zinc oxide (ZnO) nanoparticle was described. Several parameters like size and morphology of the prepared nanoparticles were characterized thorough a variety of analytical techniques such as

Formamide Synthesis through Borinic Acid Catalysed Transamidation under Mild Conditions

A highly efficient and mild transamidation of amides with amines co-catalysed by borinic acid and acetic acid has been reported. A wide range of functionalised formamides was synthesized in excellent yields, including important chiral α-amino acid derivatives, with minor racemisation being observed. Experiments suggested that the reaction rely on a cooperative catalysis involving an enhanced boron-derived Lewis acidity rather than an improved Br?nsted acidity of acetic acid. Amide bonds are reputedly difficult to activate due to their high resonance stabilization. An unusual mild activation of dimethylformamide and formamide by borinic acid 1 (see scheme), illustrated by a general formylation of a wide range of amines, including chiral α-amino esters, has been reported.

Transamidation of carboxamides catalyzed by Fe(III) and water

The highly efficient transamidation of several primary, secondary, and tertiary amides with aliphatic and aromatic amines (primary and secondary) is described. The reaction is performed in the presence of a 5 mol % concentration of different hydrated salts of Fe(III), and the results show that the presence of water is crucial. The methodology was also applied to urea and phthalimide to demonstrate its versatility and wide substrate scope. An example of its use is an intramolecular application in the synthesis of 2,3-dihydro-5H-benzo[b]-1,4- thiazepin-4-one, which is the bicyclic core of diltiazem and structurally related drugs (Budriesi, R.; Cosimelli, B.; Ioan, P.; Carosati, E.; Ugenti, M. P.; Spisani, R. Curr. Med. Chem. 2007, 14, 279-287). A plausible mechanism that explains the role of water is proposed on the basis of experimental observations and previous mechanistic suggestions for transamidation reactions catalyzed by transition metals such as copper and aluminum. This methodology represents a significant improvement over other existing methods; it can be performed in air and with wet or technical grade solvents.