2311-59-3

Usage

Uses

Used in Skincare and Cosmetic Industry:
N-Capric Acid Isopropyl Ester is used as a conditioning agent for improving the appearance and feel of hair, as well as the texture of skin. It provides lubrication and reduces roughness, making it an essential component in the formulation of skincare and cosmetic products.
Used in Perfumery and Flavoring Industry:
N-Capric Acid Isopropyl Ester is used as a valuable additive in the production of perfumes and flavorings due to its fruity or floral aroma. This makes it a popular choice for creating pleasant and appealing scents in various products.

Upstream product

• 334-48-5 1-decanoic acid 
• 112-31-2 caprinaldehyde 
• 67-63-0 isopropyl alcohol 
• 4353-06-4 2-n-nonyl-1,3-dioxolane 
• 75-26-3 isopropyl bromide 
• 112-13-0 n-decanoyl chloride 
• 693-04-9 butyl magnesium bromide 
• 64135-07-5 isopropyl 6-bromohexanoic acid ester 

Downstream Products

• 1351766-64-7 (R)-3-ethoxy-3-oxo-1-phenylpropyl decanoate 
• 72656-47-4 ethyl (R)-3-hydroxy-3-phenylpropanoate 
• 33401-74-0 ethyl (3R)-3-hydroxy-3-phenylpropionate 
• 1975-78-6 n-decanenitrile 

Relevant academic research and scientific papers

Generation and trapping of ketenes in flow

Ketenes were generated by the thermolysis of alkoxyalkynes under flow conditions, and then trapped with amines and alcohols to cleanly give amides and esters. For a 10 min reaction time, temperatures of 180, 160, and 140 °C were required for >95% conversion of EtO, iPrO, and tBuO alkoxyalkynes, respectively. Variation of the temperature and flow rate with inline monitoring of the output by IR spectroscopy allowed the kinetic parameters for the conversion of 1-ethoxy-1-octyne to be easily estimated (Ea = 105.4 kJ/mol). Trapping of the in-situ-generated ketenes by alcohols to give esters required the addition of a tertiary amine catalyst to prevent competitive [2+2] addition of the ketene to the alkoxyalkyne precursor.

Efficient microwave-assisted esterification reaction employing methanesulfonic acid supported on alumina as catalyst

A rapid and efficient protocol assisted by microwave irradiation for the synthesis of esters using methanesulfonic acid (CH3SO3H) supported on Al2O3 (AMA) as catalyst and free of solvent is described. The products were obtained in good yields and purity, with reduced reaction time, and the process is simple and environmentally benign. Copyright

Organocatalytic oxidation of aldehydes to mixed anhydrides

TEMPO catalyzes the direct oxidation of aldehydes to mixed anhydrides in the presence of a carboxylic acid. The anhydrides can be converted in situ to esters, secondary, tertiary or Weinreb amides in high yield. Oxidation of the aldehyde directly to 2-propyl esters is also possible using only catalytic amounts of acid. The oxidation reactions are rapid and take place under mild conditions.

Synthesis, antimicrobial evaluation, QSAR and in silico ADMET studies of decanoic acid derivatives

Various derivatives of decanoic acid (CD) have been synthesized and evaluated against Gram positive B. subtilis, S. aureus and Gram negative E. coli bacteria as well as against fungi C. albicans and A. niger. Quantitative structure activity relationship (QSAR) models for antimicrobial activities were developed using multiple linear regression and cross validated by leave one out (LOO) approach. QSAR studies indicated that activity against Gram positive bacteria was governed by lipophilicity of the compounds while topological steric nature of the molecule was deciding factor for antifungal activity. Further, in silico ADMET studies showed that compounds CD12, 19, 20 and 23 could be explored further for other activities.

Nickel-catalyzed cross-coupling of unactivated alkyl halides and tosylate carrying a functional group with alkyl and phenyl Grignard reagents

By the use of catalytic amounts of a nickel salt and a 1,3-butadiene, primary and secondary alkyl Grignard reagents undergo cross-coupling with alkyl bromides, iodide, and tosylate carrying a functional group such as amide, ester, and ketone at 0 °C in THF. The present procedure provides a simple, convenient, and practical method for construction of carbon chains in the presence of various functional groups. PhMgBr also gave the corresponding coupling product in a moderate yield.

Synthesis and evaluation of different fatty acid esters formulated into Precirol ATO-based lipid nanoparticles as vehicles for topical delivery

A series of isopropyl fatty esters having different chain length (C 13-C23) were synthesized and formulated in lipid nanoparticles based on Precirol ATO to evaluate their effect on the physicochemical properties of these latter. Moreover, drug loading and skin permeation of Econazole nitrate, chosen as a lipophilic model drug, were evaluated as well. The obtained nanosystems, prepared by high shear homogenization method, had a mean diameter ranging from 180 to 280 nm and showed an encapsulation efficiency of about 100%. Ex vivo permeation results demonstrated a parabolic correlation between permeation effect and chain length of the fatty esters present in the lipid nanoparticles formulated in hydrophilic gels. The maximum flux of drug was observed for the nanoparticles containing esters with 17 and 19 carbon atoms, suggesting that these formulations may constitute a potential carrier for topical delivery of econazole nitrate.

A Simple and Efficient Esterification Method

A convenient and practical esterification was realized and this reaction proceeded without a dehydrating reagent or water removal equipment. The synthesis of esters by reaction of carboxylic acids with various alcohols such as methyl, ethyl, isopropyl, isobutyl, allyl, benzyl, propargyl and decanyl alcohols were achieved with a catalytic amount of CBr4 under refluxing reaction condition.

Improved Cs2CO3 promoted O-alkylation of acids

Cesium carbonate mediated O-alkylation of carboxylic acids was efficiently carried out under mild in situ conditions to give the corresponding esters exclusively. Chiral templates including α-hydroxy and α-alkoxy acids were also converted to their corresponding esters with no observed racemization.

Direct Oxidation of Acetals and Aldehydes to Esters

One step conversion of acetals and aldehydes to esters was achieved with hydrogen peroxide (35wt% solution in water) and hydrochloric acid in alcohol. This procedure was proved to be simple and effective.

Reduction of Carboxylic Acid with 2-Propanol over Zirconia-Titania

The reduction of long carbon chain carboxylic acids or the esters with 2-propanol proceeded efficiently over zirconia-titania at atmospheric pressure, and the corresponding alcohols were obtained.Methyl 9-octadecenoate was reduced to give 9-octadecen-1-ol in a 58percent yield.