23149-33-9

Basic information

• Product Name: 1-IODO-2,4,5-TRIMETHOXYBENZENE
• Synonyms: 1-IODO-2,4,5-TRIMETHOXYBENZENE
• CAS NO: 23149-33-9
• Molecular Formula: C₉H₁₁IO₃
• Molecular Weight: 0
• Mol File: 23149-33-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 325.6°C at 760 mmHg
• Flash Point: 150.7°C
• Appearance: /
• Density: 1.602g/cm³
• Vapor Pressure: 0.000433mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 1-IODO-2,4,5-TRIMETHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-IODO-2,4,5-TRIMETHOXYBENZENE(23149-33-9)
• EPA Substance Registry System: 1-IODO-2,4,5-TRIMETHOXYBENZENE(23149-33-9)

Safety Data

• Hazardous Substances Data: 23149-33-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11IO3/c1-11-7-5-9(13-3)8(12-2)4-6(7)10/h4-5H,1-3H3

Upstream product

• 135-77-3 1,2,4-trimethoxy-benzene 
• 67-56-1 methanol 
• 7553-56-2 iodine 
• 64-17-5 ethanol 
• 149-73-5 trimethyl orthoformate 
• 490-64-2 asaronic acid 
• 20129-11-7 1-bromo-2,4,5-trimethoxybenzene 

Downstream Products

• 1702-67-6 2,2',4,4',5,5'-hexamethoxybiphenyl 
• 20129-11-7 1-bromo-2,4,5-trimethoxybenzene 
• 14894-77-0 2,3,4-trimethoxybenzonitrile 
• 213698-56-7 (2,4,5-trimethoxyphenyl)boronic acid 
• 1280155-75-0 tatanan A 

Relevant articles and documents

Mild and regioselective iodination of electron-rich aromatics with N-iodosuccinimide and catalytic trifluoroacetic acid

A variety of aromatics compounds substituted with methoxy or methyl groups were regioselectively iodinated with N-iodosuccinimide and catalytic trifluoroacetic acid with excellent yields under mild conditions and short reaction times.

Mild and regiospecific nuclear iodination of methoxybenzenes and naphthalenes with N-iodosuccinimide in acetonitrile

A wide range of methoxy substituted benzenes and naphthalenes were regiospecifically iodinated at para position with N-iodosuccinimide in acetonitrile under mild conditions in excellent yields. Methylanisoles afforded only nuclear iodination products.

Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions

Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.

Synthetic method of aryl halide taking aryl carboxylic acid as raw material

A synthetic method of an aryl halide taking aryl carboxylic acid as a raw material is characterized in that a corresponding aryl halide is formed by carrying out substitution reaction on an aryl carboxylic acid compound and haloid salt MX in an organic solvent under the condition that oxygen, a silver catalyst, a copper additive and a bidentate nitrogen ligand exist, wherein M in MX represents alkali metal or alkaline earth metal, and X represents F, Cl, Br or I. Compared with a conventional aryl halide synthetic method, the synthetic method disclosed by the invention has the obvious advantages that reaction raw materials (comprising aryl carboxylic acid and MX) are cheap and easy to obtain, the using amount of a metal catalyst is small, pollution to the environment when the oxygen is used as an oxidant is the smallest, good tolerance to various functional groups on an aromatic ring is obtained, the yield is high, and the like. The synthetic method disclosed by the invention can be widely applied to synthesis in the fields of medicine, materials, natural products and the like in industry and academia.