14894-77-0

Basic information

• Product Name: 2,4,5-TRIMETHOXYBENZONITRILE
• Synonyms: 2,4,5-TRIMETHOXYBENZONITRILE;Benzonitrile,2,4,5-triMethoxy-
• CAS NO: 14894-77-0
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.2
• Product Categories: Aromatic Nitriles
• Mol File: 14894-77-0.mol
• Article Data: 10

Chemical Properties

• Melting Point: 112-114°C
• Boiling Point: 333.8 °C at 760 mmHg
• Flash Point: 139.4 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: 2,4,5-TRIMETHOXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRIMETHOXYBENZONITRILE(14894-77-0)
• EPA Substance Registry System: 2,4,5-TRIMETHOXYBENZONITRILE(14894-77-0)

Safety Data

• Hazardous Substances Data: 14894-77-0(Hazardous Substances Data)

Usage

General Description

2,4,5-Trimethoxybenzonitrile is a chemical compound with the molecular formula C10H9NO3. It is a white crystalline solid that is sparingly soluble in water but soluble in organic solvents. 2,4,5-TRIMETHOXYBENZONITRILE is used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. It is also used in the manufacturing of dyes and other specialty chemicals. Additionally, it has been studied for its potential biological activities, including its anticancer and antifungal properties. However, its precise mechanism of action and potential toxicity are still under investigation.

InChI:InChI=1/C10H11NO3/c1-12-8-5-10(14-3)9(13-2)4-7(8)6-11/h4-5H,1-3H3

Upstream product

• 506-68-3 bromocyane 
• 135-77-3 1,2,4-trimethoxy-benzene 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 931-97-5 1-hydroxy-1-cyclohexanecarbonitrile 
• 490-64-2 asaronic acid 
• 23149-33-9 1-iodo-2,4,5-trimethoxybenzene 
• 1111-67-7 copper(I) thiocyanate 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 67-56-1 methanol 
• 2024-83-1 veratronitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 42833-66-9 2,4,5-trimethoxybenzoyl chloride 
• 2880-58-2 2-methoxy-1,4-benzoquinone 

Relevant articles and documents

Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes

Photoexcited electron-hole pairs on a semiconductor surface can engage in redox reactions with two different substrates. Similar to conventional electrosynthesis, the primary redox intermediates afford only separate oxidized and reduced products or, more rarely, combine to one addition product. Here, we report that a stable organic semiconductor material, mesoporous graphitic carbon nitride (mpg-CN), can act as a visible-light photoredox catalyst to orchestrate oxidative and reductive interfacial electron transfers to two different substrates in a two- or three-component system for direct twofold carbon–hydrogen functionalization of arenes and heteroarenes. The mpg-CN catalyst tolerates reactive radicals and strong nucleophiles, is straightforwardly recoverable by simple centrifugation of reaction mixtures, and is reusable for at least four catalytic transformations with conserved activity.

Catalytic cyanation of aryl iodides using DMF and ammonium bicarbonate as the combined source of cyanide: A dual role of copper catalysts

Cu(ii)-catalyzed cyanation of aryl iodides has been developed using DMF and ammonium bicarbonate as the combined source of cyanide. It is assumed that copper is involved both in the generation of CN units from DMF-ammonia and in the cyanation of aryl halides. A range of electron-rich and fused (hetero)aryl iodides underwent cyanation resulting in moderate to good yields.

Pd(OAc)2-catalyzed alkoxylation of arylnitriles via sp 2 C-H bond activation using cyano as the directing group

A Pd(OAc)2-catalyzed ortho-alkoxylation of arylnitrile was described. Using cyano as a directing group, the aromatic C-H bond can be functionalized efficiently to generate ortho-alkoxylated arylnitrile derivatives with moderate yields. The opti