23197-48-0

Upstream product

• 75-15-0 carbon disulfide 
• 7726-95-6 bromine 
• 90-43-7 2-Phenylphenol 
• 95-56-7 2-hydroxybromobenzene 
• 100-34-5 benzene diazonium chloride 

Downstream Products

• 1158430-60-4 C₂₄H₂₁BBrOP 
• 89827-45-2 4-bromodibenzofuran 
• 912824-85-2 2-(dibenzo[b,d]furan-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1163733-57-0 3-bromo-2-isopropoxybiphenyl 

Relevant academic research and scientific papers

Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol

Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.

The Catalyst-Controlled Regiodivergent Chlorination of Phenols

Different catalysts are demonstrated to overcome or augment a substrate's innate regioselectivity. Nagasawa's bis-thiourea catalyst was found to overcome the innate para-selectivity of electrophilic phenol chlorination, yielding ortho-chlorinated phenols that are not readily obtainable via canonical electrophilic chlorinations. Conversely, a phosphine sulfide derived from 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) was found to enhance the innate para-preference of phenol chlorination.