23226-10-0Relevant academic research and scientific papers
Iron-Catalyzed Borrowing Hydrogen C-Alkylation of Oxindoles with Alcohols
Dambatta, Mubarak B.,Polidano, Kurt,Northey, Alexander D.,Williams, Jonathan M. J.,Morrill, Louis C.
, p. 2345 - 2349 (2019/05/16)
A general and efficient iron-catalyzed C-alkylation of oxindoles has been developed. This borrowing hydrogen approach employing a (cyclopentadienone)iron carbonyl complex (2 mol %) exhibited a broad reaction scope, allowing benzylic and simple primary and secondary aliphatic alcohols to be employed as alkylating agents. A variety of oxindoles underwent selective mono-C3-alkylation in good-to-excellent isolated yields (28 examples, 50–92 % yield, 79 % average yield).
The Employment of Sodium Hydride as a Michael Donor in Palladium-catalyzed Reductions of α, β-Unsaturated Carbonyl Compounds
Liu, Ye,Mao, Yujian,Hu, Yanwei,Gui, Jingjing,Wang, Liang,Wang, Wei,Zhang, Shilei
, p. 1554 - 1558 (2019/02/16)
Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of α, β-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules. (Figure presented.).
Application of metal hydride/palladium compound catalytic reduction system in alkenyl active methylene compound reduction and reduction method
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Paragraph 0017; 0019; 0020; 0021; 0022; 0023-0026, (2019/01/08)
The invention discloses application of a metal hydride/palladium compound catalytic reduction system in alkenyl active methylene compound reduction and a reduction method. Reaction comprises the following steps that an alkenyl active methylene compound is
Reduction of 3-aminoquinoline-2,4(1H,3H)-diones and deamination of the reaction products
Klásek, Antonín,Ly?ka, Antonín,Rouchal, Michal,Rudolf, Ond?ej,R??i?ka, Ale?
, p. 595 - 612 (2014/06/09)
3-Aminoquinoline-2,4-diones were stereoselectively reduced with NaBH 4 to give cis-3-amino-3,4-dihydro-4-hydroxyquinolin-2(1H)-ones. Using triphosgene (=bis(trichloromethyl) carbonate), these compounds were converted to 3,3a-dihydrooxazolo[4,5-
C-3 alkylation of oxindole with alcohols by Pt/CeO2 catalyst in additive-free conditions
Chaudhari, Chandan,Siddiki, S. M. A. Hakim,Kon, Kenichi,Tomita, Atsuko,Tai, Yutaka,Shimizu, Ken-Ichi
, p. 1064 - 1069 (2014/04/03)
In a series of transition metal-loaded CeO2 catalysts and Pt-loaded catalysts on various supports, Pt-loaded CeO2 shows the highest activity for the selective C-3 alkylation of oxindole with octanol. The catalyst is effective for alkylation of oxindole and N-substituted oxindole with a series of substituted benzyl, linear, hetero-aryl alcohols under additive-free conditions and is recyclable. Our results demonstrate the first additive-free catalytic system for this reaction. Mechanistic studies show that this system is driven by the borrowing-hydrogen pathway. Structure-activity relationship studies show that co-presence of surface Pt0 species on Pt metal clusters and basic support is indispensable for this catalytic system. This journal is the Partner Organisations 2014.
