1075174-08-1

Basic information

• Product Name: (E)-3-benzylidene-1-phenylindolin-2-one
• Synonyms: (E)-3-benzylidene-1-phenylindolin-2-one
• CAS NO: 1075174-08-1
• Molecular Weight: 297.356
• Mol File: 1075174-08-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-3-benzylidene-1-phenylindolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-benzylidene-1-phenylindolin-2-one(1075174-08-1)
• EPA Substance Registry System: (E)-3-benzylidene-1-phenylindolin-2-one(1075174-08-1)

Safety Data

• Hazardous Substances Data: 1075174-08-1(Hazardous Substances Data)

Upstream product

• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 100-46-9 benzylamine 
• 50395-70-5 N,N-diphenylcinnamamide 
• 201230-82-2 carbon monoxide 
• 1075174-17-2 N-phenyl-2-(phenylethynyl)benzenamine 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1566616-95-2 3-benzyl-3-methyl-1-phenylindolin-2-one 
• 23226-10-0 3-benzyl-1,3-dihydro-1-phenyl-2H-indol-2-one 

Relevant articles and documents

Synthesis of (E)-3-Alkylideneindolin-2-ones by an Iron-Catalyzed Aerobic Oxidative Condensation of Csp3–H Bonds of Oxindoles and Benzylamines

A novel synthetic route for the construction of (E)-3-alkylideneindolin-2-ones through iron-catalyzed aerobic oxidative condensation of oxindoles with benzylamines has been developed. This oxidative reaction involves a sequence of C–H activation, amine self-condensation, nucleophilic addition, and C–C double bond formation. The synthetic importance of this protocol has been demonstrated by preparing tyrosine kinase inhibitors, anticonvulsant and antitumor agents, and other valuable 3-alkylideneindolin-2-one derivatives. Key intermediates are isolated and a plausible mechanistic pathway for the reaction has been discussed.

Rhenium-catalyzed acceptorless dehydrogenative coupling via dual activation of alcohols and carbonyl compounds

The rhenium hetaphydride complex was found to be a versatile, homogeneous catalyst for dehydrogenative functionalization of alcohol. The dehydrogenative C-C coupling of alcohols and carbonyl compounds was carried out in the absence of base and hydrogen acceptors to afford a series of α,β-unsaturated carbonyl compounds. A possible dual activation pathway was proposed by mechanistic investigations.

Heterobimetallic cobalt/rhodium nanoparticle-catalyzed carbonylative cycloaddition of 2-alkynylanilines to oxindoles

(Chemical Equation Presented) The cobalt-rhodium heterobimetallic nanoparticle-catalyzed synthesis of oxindoles from 2-alkynylanilines in the presence of carbon monoxide is described.